To emphasize, the p-value for the best ratio is 32 orders of magnitude more significant than the p-value for the best single metabolite. There are only ~400,000 metabolite ratios, so the p-value gain far exceeds what you might expect from multiple testing
RT @ksuhre: Using ratios between drug metabolites from the @Metabolon platform dramatically increased statistical power to detect associati…
Using ratios between drug metabolites from the @Metabolon platform dramatically increased statistical power to detect associations - likely due to a reduction in quantification uncertainty, often encountered with metabolites of high missingness, see: https
RT @ksuhre: Thanks @Eric_Fauman for pointing me to your new #metabolomics #GWAS with @jkpritch using @NgaleHealth metabolites in @uk_bioban…