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Update on checkpoint blockade therapy for lymphoma

Overview of attention for article published in Journal for Immunotherapy of Cancer, July 2015
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Title
Update on checkpoint blockade therapy for lymphoma
Published in
Journal for Immunotherapy of Cancer, July 2015
DOI 10.1186/s40425-015-0079-8
Pubmed ID
Authors

Justin Kline, Michael R. Bishop

Abstract

Although cancer cells express antigens recognizable to the immune system, tumors employ a number of diverse mechanisms aimed at subverting the host anti-tumor immune response. Tumor immune evasion pathways have been most thoroughly studied in solid tumors. However, emerging data has demonstrated that malignancies of hematopoietic origin are also able to co-opt their local environment in order to escape immune attack. Activated T cells upregulate negative costimulatory receptors, such as programmed death-1 (PD-1) and cytotoxic lymphocyte antigen-4 (CTLA-4). Engagement of PD-1 or CTLA-4 with ligands expressed on tumor cells or professional antigen presenting cells results in down-regulation of effector T cell function and represents a potent mechanism of immune evasion across a number of human cancers. Antibodies which block PD-1 / PD-L1 interactions have demonstrated remarkable activity in a number of solid tumor subtypes. Interestingly, recent data have demonstrated that in select subtypes of Hodgkin (HL) and non-Hodgkin lymphoma (NHL), the PD-1 ligands are over-expressed due to a genetic amplification of the loci encoding them. Other mechanisms of PD-L1 over-expression in lymphoma have also been elucidated. Reports from early-phase clinical trials of PD-1 blockade have demonstrated remarkable effectiveness in HL, and also appear active against some NHLs. We review the mechanisms of PD-L1 expression in lymphoma and also the early results of anti-PD-1 therapy in this disease.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 2%
United States 1 2%
Unknown 50 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 27%
Student > Ph. D. Student 7 13%
Student > Doctoral Student 5 10%
Student > Master 5 10%
Other 4 8%
Other 8 15%
Unknown 9 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 25%
Medicine and Dentistry 9 17%
Biochemistry, Genetics and Molecular Biology 7 13%
Immunology and Microbiology 5 10%
Pharmacology, Toxicology and Pharmaceutical Science 4 8%
Other 3 6%
Unknown 11 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 August 2015.
All research outputs
#19,942,887
of 25,371,288 outputs
Outputs from Journal for Immunotherapy of Cancer
#3,015
of 3,421 outputs
Outputs of similar age
#188,151
of 275,672 outputs
Outputs of similar age from Journal for Immunotherapy of Cancer
#15
of 16 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,421 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.4. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,672 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.