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Dog vaccination with EgM proteins against Echinococcus granulosus

Overview of attention for article published in Infectious Diseases of Poverty, June 2018
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Title
Dog vaccination with EgM proteins against Echinococcus granulosus
Published in
Infectious Diseases of Poverty, June 2018
DOI 10.1186/s40249-018-0425-4
Pubmed ID
Authors

Zhuang-Zhi Zhang, Gang Guo, Jun Li, Bao-Xin Shi, Li Zhao, Bao-Ping Guo, Xu Zhang, Jun-Wei Wang, Xue-Ting Zheng, Wen-Jing Qi, Li He, Wen-Bao Zhang

Abstract

Dogs play a pivotal role in the transmission of cystic echinococcosis (CE), a zoonosis caused by the tapeworm Echinococcus granulosus. We showed previously that dogs vaccinated with two E. granulosus adult-worm specific proteins, EgM9 and EgM123, emulsified with Freund's adjuvants induced significant protective efficacy in terms of reduction in worm burden and egg production after 45 days post-infection. It was not known whether this protection can be sustained using adjuvants suitable for use in dogs. Recombinant EgM9 and EgM123 were mixed with Quil A or ISCOMs for vaccinating dogs. After three vaccine injections, all the dogs were orally challenge-infected with 200 000 protoscoleces of E. granulosus. After 45 days of infection, all the dogs were euthanized and necropsied for collecting and counting E. granulosus worms. Immunoglobins, including the IgG subclasses IgG1 and IgG2, were detected in the sera of vaccinated dogs by ELISA. To determine whether the protection efficacy could be maintained after 45 days post-infection, we implemented a longevity trial to count eggs in dog faeces for 170 days after infection. The dogs vaccinated with EgM9 and EgM123 mixed with Quil A and ISCOMs showed similar protective efficacy as the proteins emulsified with Freund's adjuvants in our previous study in terms of reduction of worms and eggs at 45 days post-infection. The longevity trial showed that EgM9 protein-vaccinated group released lower number of eggs per gram compared with the egg counts in the control dogs during the dog trial study. EgM9 and EgM123 are thus suitable vaccine candidates against E. granulosus infection in dogs.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 15%
Researcher 7 13%
Student > Master 5 10%
Student > Ph. D. Student 5 10%
Student > Doctoral Student 4 8%
Other 9 17%
Unknown 14 27%
Readers by discipline Count As %
Medicine and Dentistry 13 25%
Veterinary Science and Veterinary Medicine 8 15%
Unspecified 3 6%
Agricultural and Biological Sciences 3 6%
Pharmacology, Toxicology and Pharmaceutical Science 3 6%
Other 4 8%
Unknown 18 35%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 June 2018.
All research outputs
#11,628,415
of 13,087,494 outputs
Outputs from Infectious Diseases of Poverty
#407
of 456 outputs
Outputs of similar age
#235,243
of 270,466 outputs
Outputs of similar age from Infectious Diseases of Poverty
#5
of 5 outputs
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So far Altmetric has tracked 456 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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