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Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all

Overview of attention for article published in Radiation Oncology, August 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (53rd percentile)
  • Good Attention Score compared to outputs of the same age and source (65th percentile)

Mentioned by

twitter
4 tweeters

Citations

dimensions_citation
202 Dimensions

Readers on

mendeley
192 Mendeley
Summary Twitter Dimensions citations
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Title
Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all
Published in
Radiation Oncology, August 2015
DOI 10.1186/s13014-015-0462-0
Pubmed ID
26245485
Authors

Arlene L. Oei, Lianne E. M. Vriend, Johannes Crezee, Nicolaas A. P. Franken, Przemek M. Krawczyk

Abstract

The currently available arsenal of anticancer modalities includes many DNA damaging agents that can kill malignant cells. However, efficient DNA repair mechanisms protect both healthy and cancer cells against the effects of treatment and contribute to the development of drug resistance. Therefore, anti-cancer treatments based on inflicting DNA damage can benefit from inhibition of DNA repair. Hyperthermia - treatment at elevated temperature - considerably affects DNA repair, among other cellular processes, and can thus sensitize (cancer) cells to DNA damaging agents. This effect has been known and clinically applied for many decades, but how heat inhibits DNA repair and which pathways are targeted has not been fully elucidated. In this review we attempt to summarize the known effects of hyperthermia on DNA repair pathways relevant in clinical treatment of cancer. Furthermore, we outline the relationships between the effects of heat on DNA repair and sensitization of cells to various DNA damaging agents.

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Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 192 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 2 1%
Netherlands 1 <1%
Poland 1 <1%
Belgium 1 <1%
Unknown 187 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 36 19%
Student > Master 28 15%
Student > Bachelor 27 14%
Researcher 26 14%
Other 11 6%
Other 30 16%
Unknown 34 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 40 21%
Medicine and Dentistry 29 15%
Agricultural and Biological Sciences 19 10%
Engineering 12 6%
Physics and Astronomy 8 4%
Other 37 19%
Unknown 47 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 November 2015.
All research outputs
#13,210,525
of 22,821,814 outputs
Outputs from Radiation Oncology
#599
of 2,055 outputs
Outputs of similar age
#120,443
of 264,084 outputs
Outputs of similar age from Radiation Oncology
#20
of 66 outputs
Altmetric has tracked 22,821,814 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,055 research outputs from this source. They receive a mean Attention Score of 2.7. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,084 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.

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