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Bipartite structure of the inactive mouse X chromosome

Overview of attention for article published in Genome Biology (Online Edition), August 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)

Mentioned by

24 tweeters
3 Wikipedia pages
1 research highlight platform


164 Dimensions

Readers on

195 Mendeley
1 CiteULike
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Bipartite structure of the inactive mouse X chromosome
Published in
Genome Biology (Online Edition), August 2015
DOI 10.1186/s13059-015-0728-8
Pubmed ID

Xinxian Deng, Wenxiu Ma, Vijay Ramani, Andrew Hill, Fan Yang, Ferhat Ay, Joel B. Berletch, Carl Anthony Blau, Jay Shendure, Zhijun Duan, William S. Noble, Christine M. Disteche


In mammals, one of the female X chromosomes and all imprinted genes are expressed exclusively from a single allele in somatic cells. To evaluate structural changes associated with allelic silencing, we have applied a recently developed Hi-C assay that uses DNase I for chromatin fragmentation to mouse F1 hybrid systems. We find radically different conformations for the two female mouse X chromosomes. The inactive X has two superdomains of frequent intrachromosomal contacts separated by a hinge region. Comparison with the recently reported bipartite 3D structure of the human inactive X shows that the genomic content of the superdomains differs between species, but part of the hinge is conserved and located near the Dxz4/DXZ4 locus. In mouse, the hinge region also contains a minisatellite Ds-TR, and both Dxz4 and Ds-TR appear to be anchored to the nucleolus. Genes that escape X inactivation do not cluster but are located near the periphery of the 3D structure, as are regions enriched in CTCF or RNA polymerase. Fewer short-range intrachromosomal contacts are detected for the inactive alleles of genes subject to X inactivation, compared to the active alleles and to genes that escape X inactivation. This pattern is also evident for imprinted genes, in which more chromatin contacts are detected for the expressed allele. By applying a novel Hi-C method to map allelic chromatin contacts, we discover a specific bipartite organization of the mouse inactive X chromosome that probably plays an important role in maintenance of gene silencing.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 195 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 2%
Lithuania 1 <1%
Netherlands 1 <1%
United Kingdom 1 <1%
Russia 1 <1%
Germany 1 <1%
Unknown 187 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 58 30%
Researcher 37 19%
Student > Bachelor 24 12%
Student > Master 15 8%
Student > Doctoral Student 13 7%
Other 30 15%
Unknown 18 9%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 91 47%
Agricultural and Biological Sciences 59 30%
Computer Science 8 4%
Medicine and Dentistry 7 4%
Neuroscience 3 2%
Other 7 4%
Unknown 20 10%

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2019.
All research outputs
of 17,155,918 outputs
Outputs from Genome Biology (Online Edition)
of 3,562 outputs
Outputs of similar age
of 240,685 outputs
Outputs of similar age from Genome Biology (Online Edition)
of 2 outputs
Altmetric has tracked 17,155,918 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,562 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.4. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,685 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them