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Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate gastric cancer progression

Overview of attention for article published in Journal of Experimental & Clinical Cancer Research, August 2015
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2 tweeters

Citations

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234 Dimensions

Readers on

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59 Mendeley
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Title
Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate gastric cancer progression
Published in
Journal of Experimental & Clinical Cancer Research, August 2015
DOI 10.1186/s13046-015-0197-7
Pubmed ID
Authors

Weizhao Peng, Shuang Si, Qingxia Zhang, Chaofeng Li, Fang Zhao, Fang Wang, Jia Yu, Ren Ma

Abstract

Long noncoding RNAs (lncRNAs) have recently emerged as important regulators in governing fundamental biological processes, and many of which are likely to have functional roles in tumorigenesis. Maternally expressed gene 3 (MEG3) gene encodes a lncRNA whose expression is lost in an expanding list of primary human tumors and tumor cell lines, however its biological role and regulatory mechanism in gastric cancer (GC) development and progression are poorly defined. Quantitative RT-PCR analysis was used to determine whether aberrant MEG3 expression was associated with GC patients pTNM stage and pM state. Furthermore, the effect of ectopic expression of MEG3 on cell proliferation, migration, invasion and cell apoptosis was assessed by using CCK-8, wound healing, transwell invasion assays and flow cytometric analysis, respectively, in GC cell lines HGC-27 and MGC-803. Moreover, the competing endogenous RNA (ceRNA) activity of MEG3 on miR-181a was investigated via luciferase reporter assay and immunoblot analysis. MEG3 is decreased in GC patients and cell lines, and its expression was associated with metastatic GC. Furthermore, ectopic expression of MEG3 in HGC-27 and MGC-803 cells inhibited cell proliferation, migration, invasion, and promoted cell apoptosis, which might be due to MEG3 sequestering oncogenic miR-181 s in GC cells. Furthermore, MEG3 could up-regulated Bcl-2 via its competing endogenous RNA (ceRNA) activity on miR-181a. These findings suggest that lncRNA MEG3, a ceRNA of miR-181 s, could regulate gastric carcinogenesis and may serve as a potential target for antineoplastic therapies.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 59 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 22%
Student > Ph. D. Student 13 22%
Researcher 9 15%
Student > Bachelor 4 7%
Student > Postgraduate 4 7%
Other 4 7%
Unknown 12 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 20 34%
Agricultural and Biological Sciences 12 20%
Medicine and Dentistry 8 14%
Nursing and Health Professions 1 2%
Arts and Humanities 1 2%
Other 4 7%
Unknown 13 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 September 2015.
All research outputs
#9,480,074
of 12,378,687 outputs
Outputs from Journal of Experimental & Clinical Cancer Research
#358
of 733 outputs
Outputs of similar age
#152,433
of 242,498 outputs
Outputs of similar age from Journal of Experimental & Clinical Cancer Research
#9
of 24 outputs
Altmetric has tracked 12,378,687 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 733 research outputs from this source. They receive a mean Attention Score of 2.4. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,498 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.