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Evaluation of High Resolution Melting analysis as an alternate tool to screen for risk alleles associated with small kidneys in Indian newborns

Overview of attention for article published in BMC Nephrology, October 2011
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  • Good Attention Score compared to outputs of the same age and source (68th percentile)

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Title
Evaluation of High Resolution Melting analysis as an alternate tool to screen for risk alleles associated with small kidneys in Indian newborns
Published in
BMC Nephrology, October 2011
DOI 10.1186/1471-2369-12-60
Pubmed ID
Authors

Ashwini Raghavendra, Annes Siji, TS Sridhar, Kishore Phadke, Anil Vasudevan

Abstract

Single nucleotide polymorphisms (SNPs) are the most common forms of sequence variations in the human genome. They contribute to the human phenotypic spectrum and are associated with variations in response to pathogens, drugs and vaccines. Recently, SNPs in three human genes involved in kidney development (RET, PAX2 and ALDH1A2) have been reported to be associated with variation in renal size and function. These known SNPs could potentially be used in the clinic as markers for identifying babies who may have smaller kidneys and permit close follow up for early detection of hypertension and acquired renal dysfunction. The aim of this study was to evaluate the use of High Resolution Melting technique (HRM) as a tool for detecting the known SNPs in these three genes in comparison to sequencing which is the gold standard.

X Demographics

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 3%
United States 1 3%
Unknown 33 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 17%
Student > Ph. D. Student 5 14%
Student > Bachelor 4 11%
Researcher 4 11%
Student > Postgraduate 3 9%
Other 6 17%
Unknown 7 20%
Readers by discipline Count As %
Medicine and Dentistry 13 37%
Agricultural and Biological Sciences 8 23%
Immunology and Microbiology 1 3%
Linguistics 1 3%
Psychology 1 3%
Other 3 9%
Unknown 8 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 November 2011.
All research outputs
#13,357,126
of 22,656,971 outputs
Outputs from BMC Nephrology
#1,035
of 2,451 outputs
Outputs of similar age
#86,031
of 140,785 outputs
Outputs of similar age from BMC Nephrology
#5
of 16 outputs
Altmetric has tracked 22,656,971 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,451 research outputs from this source. They receive a mean Attention Score of 4.6. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 140,785 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.