Title |
Evaluation of High Resolution Melting analysis as an alternate tool to screen for risk alleles associated with small kidneys in Indian newborns
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Published in |
BMC Nephrology, October 2011
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DOI | 10.1186/1471-2369-12-60 |
Pubmed ID | |
Authors |
Ashwini Raghavendra, Annes Siji, TS Sridhar, Kishore Phadke, Anil Vasudevan |
Abstract |
Single nucleotide polymorphisms (SNPs) are the most common forms of sequence variations in the human genome. They contribute to the human phenotypic spectrum and are associated with variations in response to pathogens, drugs and vaccines. Recently, SNPs in three human genes involved in kidney development (RET, PAX2 and ALDH1A2) have been reported to be associated with variation in renal size and function. These known SNPs could potentially be used in the clinic as markers for identifying babies who may have smaller kidneys and permit close follow up for early detection of hypertension and acquired renal dysfunction. The aim of this study was to evaluate the use of High Resolution Melting technique (HRM) as a tool for detecting the known SNPs in these three genes in comparison to sequencing which is the gold standard. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 200% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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India | 1 | 3% |
United States | 1 | 3% |
Unknown | 33 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 6 | 17% |
Student > Ph. D. Student | 5 | 14% |
Student > Bachelor | 4 | 11% |
Researcher | 4 | 11% |
Student > Postgraduate | 3 | 9% |
Other | 6 | 17% |
Unknown | 7 | 20% |
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Agricultural and Biological Sciences | 8 | 23% |
Immunology and Microbiology | 1 | 3% |
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Psychology | 1 | 3% |
Other | 3 | 9% |
Unknown | 8 | 23% |