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Isolation of methyl gamma linolenate from spirulina platensis using flash chromatography and its apoptosis inducing effect

Overview of attention for article published in BMC Complementary Medicine and Therapies, August 2015
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Title
Isolation of methyl gamma linolenate from spirulina platensis using flash chromatography and its apoptosis inducing effect
Published in
BMC Complementary Medicine and Therapies, August 2015
DOI 10.1186/s12906-015-0771-8
Pubmed ID
Authors

Jubie S., Dhanabal S. P., Chaitanya M. V. N. L.

Abstract

Isolation of methyl gamma linolenate from Spirulina platensis using flash chromatography and its apoptosis inducing effect against human lung carcinoma A- 549 cell lines. Gamma linolenic acid is an important omega-6 polyunsaturated fatty acid (PUFA) of medicinal interest was isolated from microalgae Spirulina platensis using flash chromatography system (Isolera system) as its methyl ester. The isolated methyl gamma linolenate was characterized by IR, (1)H NMR, (13)C NMR and mass spectral analysis and the data were consistent with the structure. The percentage yield of isolated methyl gamma linolenate is found to be 71 % w/w, which is a very good yield in comparison to other conventional methods. It was subjected to in-vitro cytotoxic screening on A-549 lung cancer cell lines using SRB assay and result was compared with standard rutin. It may be concluded that the Flash chromatography system plays a major role in improving the yield for theisolation of methyl gamma linoleate from Spirulina platensis and the isolated molecule is a potent cytotoxicagent towards human lung carcinoma cell lines, however it may be further taken up for an extensive study.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 20%
Student > Bachelor 5 11%
Unspecified 3 7%
Lecturer 3 7%
Student > Master 3 7%
Other 8 18%
Unknown 14 31%
Readers by discipline Count As %
Chemistry 6 13%
Agricultural and Biological Sciences 6 13%
Biochemistry, Genetics and Molecular Biology 5 11%
Pharmacology, Toxicology and Pharmaceutical Science 4 9%
Unspecified 3 7%
Other 7 16%
Unknown 14 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 August 2015.
All research outputs
#20,286,650
of 22,821,814 outputs
Outputs from BMC Complementary Medicine and Therapies
#2,978
of 3,630 outputs
Outputs of similar age
#220,970
of 264,230 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#76
of 95 outputs
Altmetric has tracked 22,821,814 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,630 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,230 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.