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LC3B globular structures correlate with survival in esophageal adenocarcinoma

Overview of attention for article published in BMC Cancer, August 2015
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Title
LC3B globular structures correlate with survival in esophageal adenocarcinoma
Published in
BMC Cancer, August 2015
DOI 10.1186/s12885-015-1574-5
Pubmed ID
Authors

Shereen El-Mashed, Tracey R. O’Donovan, Elaine W. Kay, Ayat R. Abdallah, Mary-Clare Cathcart, Jacintha O’Sullivan, Anthony O’Grady, John Reynolds, Seamus O’Reilly, Gerald C. O’Sullivan, Sharon L. McKenna

Abstract

Esophageal adenocarcinoma has the fastest growing incidence of any solid tumor in the Western world. Prognosis remains poor with overall five-year survival rates under 25 %. Only a limited number of patients benefit from chemotherapy and there are no biomarkers that can predict outcome. Previous studies have indicated that induction of autophagy can influence various aspects of tumor cell biology, including chemosensitivity. The objective of this study was to assess whether expression of the autophagy marker (LC3B) correlated with patient outcome. Esophageal adenocarcinoma tumor tissue from two independent sites, was examined retrospectively. Tumors from 104 neoadjuvant naïve patients and 48 patients post neoadjuvant therapy were assembled into tissue microarrays prior to immunohistochemical analysis. Kaplan-Meier survival curves and log-rank tests were used to assess impact of LC3B expression on survival. Cox regression was used to examine association with clinical risk factors. A distinct globular pattern of LC3B expression was found to be predictive of outcome in both patient groups, irrespective of treatment (p < 0.001). Multivariate analysis found that this was a strong independent predictor of poor prognosis (p < 0.001). This distinctive staining pattern of LC3B represents a novel prognostic marker for resectable esophageal adenocarcinoma.

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The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 21%
Researcher 4 14%
Student > Bachelor 3 11%
Student > Postgraduate 3 11%
Student > Master 3 11%
Other 4 14%
Unknown 5 18%
Readers by discipline Count As %
Medicine and Dentistry 9 32%
Biochemistry, Genetics and Molecular Biology 7 25%
Agricultural and Biological Sciences 4 14%
Earth and Planetary Sciences 1 4%
Psychology 1 4%
Other 0 0%
Unknown 6 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 May 2016.
All research outputs
#14,234,315
of 22,821,814 outputs
Outputs from BMC Cancer
#3,360
of 8,301 outputs
Outputs of similar age
#136,456
of 264,494 outputs
Outputs of similar age from BMC Cancer
#59
of 147 outputs
Altmetric has tracked 22,821,814 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,301 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,494 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 147 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.