↓ Skip to main content

Anti-citrullinated protein antibodies contribute to platelet activation in rheumatoid arthritis

Overview of attention for article published in Arthritis Research & Therapy, August 2015
Altmetric Badge

About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (61st percentile)

Mentioned by

twitter
5 tweeters

Citations

dimensions_citation
53 Dimensions

Readers on

mendeley
48 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Anti-citrullinated protein antibodies contribute to platelet activation in rheumatoid arthritis
Published in
Arthritis Research & Therapy, August 2015
DOI 10.1186/s13075-015-0665-7
Pubmed ID
Authors

Kim L.L. Habets, Leendert A. Trouw, E.W. Nivine Levarht, Suzanne J.A. Korporaal, Petra A.M. Habets, Philip de Groot, Tom W.J. Huizinga, René E.M. Toes

Abstract

Although the role of platelets in rheumatoid arthritis (RA) is relatively unexplored, recent studies point towards a contribution of platelets in arthritis. We now set out to determine platelet phenotype in RA and studied whether this could be influenced by the presence of Anti-Citrullinated Protein Antibodies (ACPA). Platelets from healthy controls were incubated in the presence of either plasma of RA patients or age/gender matched healthy controls; plasma from ACPA(neg) or ACPA(pos) patients or in the presence of plate-bound ACPA. Characteristics of platelets isolated from RA patients were correlated to disease activity. Platelets isolated from healthy controls display markers of platelet activation in the presence of plasma derived from RA patients, as determined by P-selectin expression, formation of aggregates and secretion of sCD40L. Furthermore, levels of P-selectin expression and sCD40L release correlated with high ACPA titers. In accordance, an enhanced platelet activation was observed after incubation with ACPA(pos) plasma versus ACPA(neg) plasma. Pre-incubation of platelets with blocking antibodies directed against FcyRIIa, completely inhibited the ACPA-mediated activation. In addition, both expression of P-selectin as number of platelets correlated with DAS44, CRP levels and ACPA-status and ACPA levels. We now show for the first time that ACPA can mediate an FcyRIIa dependent activation of platelets. As ACPA can be detected several years before disease onset and activated platelets contribute to vascular permeability, these data implicate a possible role for ACPA-mediated activation of platelets in arthritis (onset).

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Turkey 1 2%
Switzerland 1 2%
Unknown 45 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 21%
Researcher 9 19%
Student > Ph. D. Student 8 17%
Student > Doctoral Student 4 8%
Student > Postgraduate 3 6%
Other 5 10%
Unknown 9 19%
Readers by discipline Count As %
Immunology and Microbiology 10 21%
Medicine and Dentistry 10 21%
Biochemistry, Genetics and Molecular Biology 8 17%
Agricultural and Biological Sciences 6 13%
Psychology 1 2%
Other 2 4%
Unknown 11 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2019.
All research outputs
#7,497,034
of 14,212,940 outputs
Outputs from Arthritis Research & Therapy
#1,337
of 2,287 outputs
Outputs of similar age
#89,171
of 235,578 outputs
Outputs of similar age from Arthritis Research & Therapy
#1
of 1 outputs
Altmetric has tracked 14,212,940 research outputs across all sources so far. This one is in the 46th percentile – i.e., 46% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,287 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,578 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them