Title |
Oxidized lipids keep heat shock chaperones busy: new insights on the deficiencies of tumour-associated dendritic cells
|
---|---|
Published in |
Journal for Immunotherapy of Cancer, June 2018
|
DOI | 10.1186/s40425-018-0373-3 |
Pubmed ID | |
Authors |
Paula Nunes-Hasler |
Abstract |
In a recent publication in Nature Communications the group of Dr. Dmitry Gabrilovich takes us one step closer to understanding why lipid accumulation impairs the function of tumour-associated dendritic cells (DCs). In this study, the authors present two surprising and significant findings. First, they show that in mouse DCs oxidized lipids function as a sink that traps the heat shock chaperone HSP70, a molecular target of emerging anti-cancer strategies. Secondly, they find that HSP70 in turn regulates the trafficking of peptide-loaded major histocompatibility complex class I (pMHC-I) molecules, a complex that triggers the proliferation of cancer-killing T cells. These observations are discussed briefly in the context of lipid droplet function and pMHC-I trafficking in tumour-associated DCs, as well as HSP70's pleiotropic and incompletely understood roles - and what they mean for future cancer therapy designs. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 60% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 40% |
Scientists | 1 | 20% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 10 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 3 | 30% |
Student > Master | 2 | 20% |
Professor | 1 | 10% |
Other | 1 | 10% |
Researcher | 1 | 10% |
Other | 1 | 10% |
Unknown | 1 | 10% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 5 | 50% |
Agricultural and Biological Sciences | 1 | 10% |
Immunology and Microbiology | 1 | 10% |
Unknown | 3 | 30% |