Title |
Network analysis of microRNAs and their regulation in human ovarian cancer
|
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Published in |
BMC Systems Biology, November 2011
|
DOI | 10.1186/1752-0509-5-183 |
Pubmed ID | |
Authors |
Sebastian Schmeier, Ulf Schaefer, Magbubah Essack, Vladimir B Bajic |
Abstract |
MicroRNAs (miRNAs) are small non-coding RNA molecules that repress the translation of messenger RNAs (mRNAs) or degrade mRNAs. These functions of miRNAs allow them to control key cellular processes such as development, differentiation and apoptosis, and they have also been implicated in several cancers such as leukaemia, lung, pancreatic and ovarian cancer (OC). Unfortunately, the specific machinery of miRNA regulation, involving transcription factors (TFs) and transcription co-factors (TcoFs), is not well understood. In the present study we focus on computationally deciphering the underlying network of miRNAs, their targets, and their control mechanisms that have an influence on OC development. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 5 | 7% |
Germany | 3 | 4% |
United Kingdom | 2 | 3% |
India | 1 | 1% |
Canada | 1 | 1% |
Hungary | 1 | 1% |
Japan | 1 | 1% |
Mexico | 1 | 1% |
Unknown | 54 | 78% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 19 | 28% |
Student > Ph. D. Student | 15 | 22% |
Student > Master | 9 | 13% |
Professor > Associate Professor | 7 | 10% |
Student > Bachelor | 5 | 7% |
Other | 11 | 16% |
Unknown | 3 | 4% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 38 | 55% |
Medicine and Dentistry | 9 | 13% |
Biochemistry, Genetics and Molecular Biology | 6 | 9% |
Computer Science | 4 | 6% |
Engineering | 2 | 3% |
Other | 5 | 7% |
Unknown | 5 | 7% |