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Inhibitory effect of Samul-tang on retinal neovascularization in oxygen-induced retinopathy

Overview of attention for article published in BMC Complementary and Alternative Medicine, August 2015
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Title
Inhibitory effect of Samul-tang on retinal neovascularization in oxygen-induced retinopathy
Published in
BMC Complementary and Alternative Medicine, August 2015
DOI 10.1186/s12906-015-0800-7
Pubmed ID
Authors

Yun Mi Lee, Chan-Sik Kim, Kyuhyung Jo, Eun Jin Sohn, Jin Sook Kim, Junghyun Kim

Abstract

Retinal neovascularization is a common cause of vision loss in proliferative diabetic retinopathy, retinopathy of prematurity and age-related macular degeneration. Samul-tang (SMT) is a widely used traditional herbal medicine in East Asia and is also known as Shimotsu-to in Japanese and Si-Wu decoction in Chinese. This study was designed to evaluate the inhibitory effect of SMT on retinal pathogenic angiogenesis in a mouse model of oxygen-induced retinopathy (OIR). The mice were exposed to a 75 % concentration of oxygen for five days, starting on postnatal day 7 (P7-P12). The mice were then exposed to room air and were intraperitoneally injected with SMT (10 mg/kg or 50 mg/kg) once per day for five days (P12-P16). On P17, we measured retinal neovascularization and evaluated both the expression of angiogenesis-related proteins and changes in the gene expression level in the mRNA. SMT reduced the area of the central retina and reduced retinal neovascularization in OIR mice. The protein array revealed that SMT reduced the level of SDF-1 protein expression. Quantitative real-time PCR revealed that the HIF-1α, SDF-1, CXCR4 and VEGF mRNA levels in the retinas of OIR mice were elevated compared with those of normal control mice. However, SMT decreased the levels of HIF-1α, SDF-1, CXCR4 and VEGF mRNA in OIR mice. We are the first to elucidate that SMT inhibits the retinal pathogenic angiogenesis induced by ischemic retinopathy in OIR mice. SMT significantly inhibited retinal neovascularization by downregulating HIF-1α, SDF-1, CXCR4 and VEGF. Based on the results of our study, SMT could be a useful herbal medicine for treating ischemic retinopathy.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 19 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 21%
Other 2 11%
Student > Doctoral Student 2 11%
Student > Ph. D. Student 2 11%
Student > Bachelor 2 11%
Other 3 16%
Unknown 4 21%
Readers by discipline Count As %
Medicine and Dentistry 9 47%
Pharmacology, Toxicology and Pharmaceutical Science 2 11%
Biochemistry, Genetics and Molecular Biology 1 5%
Nursing and Health Professions 1 5%
Chemistry 1 5%
Other 0 0%
Unknown 5 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 August 2015.
All research outputs
#4,559,455
of 5,480,898 outputs
Outputs from BMC Complementary and Alternative Medicine
#1,415
of 1,632 outputs
Outputs of similar age
#153,556
of 191,632 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#76
of 85 outputs
Altmetric has tracked 5,480,898 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,632 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 85 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.