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Autism spectrum disorder: prospects for treatment using gene therapy

Overview of attention for article published in Molecular Autism, June 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (95th percentile)
  • Good Attention Score compared to outputs of the same age and source (70th percentile)

Mentioned by

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92 X users
wikipedia
1 Wikipedia page
reddit
1 Redditor

Citations

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42 Dimensions

Readers on

mendeley
179 Mendeley
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Title
Autism spectrum disorder: prospects for treatment using gene therapy
Published in
Molecular Autism, June 2018
DOI 10.1186/s13229-018-0222-8
Pubmed ID
Authors

Matthew Benger, Maria Kinali, Nicholas D. Mazarakis

Abstract

Autism spectrum disorder (ASD) is characterised by the concomitant occurrence of impaired social interaction; restricted, perseverative and stereotypical behaviour; and abnormal communication skills. Recent epidemiological studies have reported a dramatic increase in the prevalence of ASD with as many as 1 in every 59 children being diagnosed with ASD. The fact that ASD appears to be principally genetically driven, and may be reversible postnatally, has raised the exciting possibility of using gene therapy as a disease-modifying treatment. Such therapies have already started to seriously impact on human disease and particularly monogenic disorders (e.g. metachromatic leukodystrophy, SMA type 1). In regard to ASD, technical advances in both our capacity to model the disorder in animals and also our ability to deliver genes to the central nervous system (CNS) have led to the first preclinical studies in monogenic ASD, involving both gene replacement and silencing. Furthermore, our increasing awareness and understanding of common dysregulated pathways in ASD have broadened gene therapy's potential scope to include various polygenic ASDs. As this review highlights, despite a number of outstanding challenges, gene therapy has excellent potential to address cognitive dysfunction in ASD.

X Demographics

X Demographics

The data shown below were collected from the profiles of 92 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 179 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 179 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 28 16%
Student > Master 26 15%
Student > Ph. D. Student 24 13%
Researcher 11 6%
Other 10 6%
Other 28 16%
Unknown 52 29%
Readers by discipline Count As %
Neuroscience 27 15%
Biochemistry, Genetics and Molecular Biology 17 9%
Medicine and Dentistry 17 9%
Psychology 16 9%
Agricultural and Biological Sciences 13 7%
Other 32 18%
Unknown 57 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 64. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2023.
All research outputs
#666,077
of 25,468,789 outputs
Outputs from Molecular Autism
#61
of 720 outputs
Outputs of similar age
#14,499
of 341,695 outputs
Outputs of similar age from Molecular Autism
#4
of 10 outputs
Altmetric has tracked 25,468,789 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 720 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.2. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,695 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.