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A subset of patients with systemic lupus erythematosus fails to degrade DNA from multiple clinically relevant sources

Overview of attention for article published in Arthritis Research & Therapy, August 2015
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  • Above-average Attention Score compared to outputs of the same age (55th percentile)
  • Average Attention Score compared to outputs of the same age and source

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4 tweeters

Citations

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36 Dimensions

Readers on

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53 Mendeley
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Title
A subset of patients with systemic lupus erythematosus fails to degrade DNA from multiple clinically relevant sources
Published in
Arthritis Research & Therapy, August 2015
DOI 10.1186/s13075-015-0726-y
Pubmed ID
Authors

Jonatan Leffler, Katarzyna Ciacma, Birgitta Gullstrand, Anders A. Bengtsson, Myriam Martin, Anna M. Blom

Abstract

Patients with systemic lupus erythematosus (SLE) have a decreased ability to clear cell remnants and multiple deficiencies in the ability to degrade cellular chromatin have been linked to the disease. Since the discovery of neutrophil extracellular traps (NETs), a renewed interest has been sparked in this field of research with multiple studies reporting a decreased ability of patients with SLE to degrade NETs. In this study we extend these findings by investigating the ability of patients with SLE to degrade chromatin from multiple clinically relevant sources. We use flow cytometry in combination with NET degradation and DNA zymogram assays to investigate the ability of sera from SLE patients to degrade chromatin from three different sources of DNA such as NETs, apoptotic and necrotic cells. This ability was further associated with clinical manifestations. We found that 61 % of the patients had an affected degradation of at least one chromatin source. Further, degradation of NETs correlated with degradation of chromatin from secondary necrotic cells but not with degradation of chromatin from primary necrotic cells. Patients who fail to degrade several forms of DNA more often display anti-nuclear and nephritic involvement whereas this is not observed in patients with decreased ability to degrade chromatin from primary necrotic cells. The majority of patients with SLE has a decreased ability to degrade chromatin from clinically relevant sources. This decreased ability is further reflected in their clinical presentation.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 52 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 21%
Student > Bachelor 9 17%
Researcher 9 17%
Student > Master 5 9%
Student > Doctoral Student 4 8%
Other 6 11%
Unknown 9 17%
Readers by discipline Count As %
Immunology and Microbiology 9 17%
Medicine and Dentistry 9 17%
Agricultural and Biological Sciences 8 15%
Biochemistry, Genetics and Molecular Biology 8 15%
Chemistry 2 4%
Other 5 9%
Unknown 12 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 August 2015.
All research outputs
#7,028,486
of 12,451,992 outputs
Outputs from Arthritis Research & Therapy
#1,237
of 1,983 outputs
Outputs of similar age
#100,094
of 235,516 outputs
Outputs of similar age from Arthritis Research & Therapy
#21
of 46 outputs
Altmetric has tracked 12,451,992 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,983 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,516 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.