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Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice

Overview of attention for article published in Molecular Neurodegeneration, October 2011
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  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

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1 X user
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1 patent

Citations

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134 Dimensions

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200 Mendeley
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Title
Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice
Published in
Molecular Neurodegeneration, October 2011
DOI 10.1186/1750-1326-6-73
Pubmed ID
Authors

Ya-Fei Xu, Yong-Jie Zhang, Wen-Lang Lin, Xiangkun Cao, Caroline Stetler, Dennis W Dickson, Jada Lewis, Leonard Petrucelli

Abstract

Abnormal distribution, modification and aggregation of transactivation response DNA-binding protein 43 (TDP-43) are the hallmarks of multiple neurodegenerative diseases, especially frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral sclerosis (ALS). Researchers have identified 44 mutations in the TARDBP gene that encode TDP-43 as causative for cases of sporadic and familial ALS http://www.molgen.ua.ac.be/FTDMutations/. Certain mutant forms of TDP-43, such as M337V, are associated with increased low molecular weight (LMW) fragments compared to wild-type (WT) TDP-43 and cause neuronal apoptosis and developmental delay in chick embryos. Such findings support a direct link between altered TDP-43 function and neurodegeneration.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 200 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
United Kingdom 1 <1%
Belgium 1 <1%
Spain 1 <1%
United States 1 <1%
Unknown 195 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 47 24%
Student > Bachelor 30 15%
Researcher 28 14%
Student > Master 24 12%
Student > Doctoral Student 9 5%
Other 23 12%
Unknown 39 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 63 32%
Neuroscience 39 20%
Biochemistry, Genetics and Molecular Biology 23 12%
Medicine and Dentistry 20 10%
Nursing and Health Professions 4 2%
Other 7 4%
Unknown 44 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2016.
All research outputs
#6,376,108
of 22,656,971 outputs
Outputs from Molecular Neurodegeneration
#564
of 842 outputs
Outputs of similar age
#38,923
of 140,468 outputs
Outputs of similar age from Molecular Neurodegeneration
#3
of 13 outputs
Altmetric has tracked 22,656,971 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 842 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.0. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 140,468 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.