Title |
Comparative liver transcriptome analysis in ducklings infected with duck hepatitis A virus 3 (DHAV-3) at 12 and 48 hours post-infection through RNA-seq
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Published in |
Veterinary Research, June 2018
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DOI | 10.1186/s13567-018-0545-7 |
Pubmed ID | |
Authors |
Xuelian Zhang, Chong Cao, Yue Liu, Haihui Qi, Wenjing Zhang, Chunxue Hao, Haotian Chen, Qi Zhang, Wenlong Zhang, Mingchun Gao, Junwei Wang, Bo Ma |
Abstract |
Duck hepatitis A virus 3 (DHAV-3), the only member of the novel genus Avihepatovirus, in the family Picornaviridae, can cause significant economic losses for duck farms in China. Reports on the pathogenicity and the antiviral molecular mechanisms of the lethal DHAV-3 strain in ducklings are inadequate and remain poorly understood. We conducted global gene expression profiling and screened differentially expressed genes (DEG) of duckling liver tissues infected with lethal DHAV-3. There were 1643 DEG and 8979 DEG when compared with mock ducklings at 12 hours post-infection (hpi) and at 48 hpi, respectively. Gene pathway analysis of DEG highlighted mainly biological processes involved in metabolic pathways, host immune responses, and viral invasion. The results may provide valuable information for us to explore the pathogenicity of the virulent DHAV-3 strain and to improve our understanding of host-virus interactions. |
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Geographical breakdown
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 3 | 21% |
Student > Master | 2 | 14% |
Student > Ph. D. Student | 2 | 14% |
Student > Doctoral Student | 1 | 7% |
Student > Bachelor | 1 | 7% |
Other | 1 | 7% |
Unknown | 4 | 29% |
Readers by discipline | Count | As % |
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Veterinary Science and Veterinary Medicine | 3 | 21% |
Biochemistry, Genetics and Molecular Biology | 3 | 21% |
Medicine and Dentistry | 2 | 14% |
Immunology and Microbiology | 1 | 7% |
Agricultural and Biological Sciences | 1 | 7% |
Other | 0 | 0% |
Unknown | 4 | 29% |