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Comparative liver transcriptome analysis in ducklings infected with duck hepatitis A virus 3 (DHAV-3) at 12 and 48 hours post-infection through RNA-seq

Overview of attention for article published in Veterinary Research, June 2018
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Title
Comparative liver transcriptome analysis in ducklings infected with duck hepatitis A virus 3 (DHAV-3) at 12 and 48 hours post-infection through RNA-seq
Published in
Veterinary Research, June 2018
DOI 10.1186/s13567-018-0545-7
Pubmed ID
Authors

Xuelian Zhang, Chong Cao, Yue Liu, Haihui Qi, Wenjing Zhang, Chunxue Hao, Haotian Chen, Qi Zhang, Wenlong Zhang, Mingchun Gao, Junwei Wang, Bo Ma

Abstract

Duck hepatitis A virus 3 (DHAV-3), the only member of the novel genus Avihepatovirus, in the family Picornaviridae, can cause significant economic losses for duck farms in China. Reports on the pathogenicity and the antiviral molecular mechanisms of the lethal DHAV-3 strain in ducklings are inadequate and remain poorly understood. We conducted global gene expression profiling and screened differentially expressed genes (DEG) of duckling liver tissues infected with lethal DHAV-3. There were 1643 DEG and 8979 DEG when compared with mock ducklings at 12 hours post-infection (hpi) and at 48 hpi, respectively. Gene pathway analysis of DEG highlighted mainly biological processes involved in metabolic pathways, host immune responses, and viral invasion. The results may provide valuable information for us to explore the pathogenicity of the virulent DHAV-3 strain and to improve our understanding of host-virus interactions.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 14 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 21%
Student > Master 2 14%
Student > Ph. D. Student 2 14%
Student > Doctoral Student 1 7%
Student > Bachelor 1 7%
Other 1 7%
Unknown 4 29%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 3 21%
Biochemistry, Genetics and Molecular Biology 3 21%
Medicine and Dentistry 2 14%
Immunology and Microbiology 1 7%
Agricultural and Biological Sciences 1 7%
Other 0 0%
Unknown 4 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 June 2018.
All research outputs
#20,663,600
of 25,385,509 outputs
Outputs from Veterinary Research
#1,035
of 1,337 outputs
Outputs of similar age
#265,754
of 341,526 outputs
Outputs of similar age from Veterinary Research
#32
of 36 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
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