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Infrequent false positive [18F]flutemetamol PET signal is resolved by combined histological assessment of neuritic and diffuse plaques

Overview of attention for article published in Alzheimer's Research & Therapy, June 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)

Mentioned by

news
2 news outlets

Citations

dimensions_citation
22 Dimensions

Readers on

mendeley
25 Mendeley
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Title
Infrequent false positive [18F]flutemetamol PET signal is resolved by combined histological assessment of neuritic and diffuse plaques
Published in
Alzheimer's Research & Therapy, June 2018
DOI 10.1186/s13195-018-0387-6
Pubmed ID
Authors

Milos D. Ikonomovic, Enrico R. Fantoni, Gill Farrar, Stephen Salloway

Abstract

The performance of [18F]flutemetamol amyloid PET against histopathological standards of truth was the subject of our recent article in Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring (2017;9:25-34). This viewpoint article addresses infrequently observed discordance between visual [18F]flutemetamol PET image readings and histopathology based solely on neuritic plaque assessment by CERAD criteria, which is resolved by assessing both neuritic and diffuse plaques and/or brain atrophy. [18F]flutemetamol PET signal corresponds predominantly to neuritic plaque pathology but is also influenced by the presence of diffuse plaques. This could allow for detection of diffuse amyloid deposits in the early stages of AD dementia, particularly in the striatum where diffuse amyloid is most commonly observed.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Other 7 28%
Researcher 4 16%
Student > Ph. D. Student 3 12%
Student > Doctoral Student 2 8%
Student > Master 2 8%
Other 1 4%
Unknown 6 24%
Readers by discipline Count As %
Medicine and Dentistry 11 44%
Neuroscience 3 12%
Psychology 1 4%
Biochemistry, Genetics and Molecular Biology 1 4%
Chemistry 1 4%
Other 0 0%
Unknown 8 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 June 2018.
All research outputs
#2,435,787
of 25,050,563 outputs
Outputs from Alzheimer's Research & Therapy
#522
of 1,424 outputs
Outputs of similar age
#48,504
of 335,167 outputs
Outputs of similar age from Alzheimer's Research & Therapy
#23
of 32 outputs
Altmetric has tracked 25,050,563 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,424 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.6. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,167 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 32 others from the same source and published within six weeks on either side of this one. This one is in the 28th percentile – i.e., 28% of its contemporaries scored the same or lower than it.