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Structural elucidation of some antimicrobial constituents from the leaf latex of Aloe trigonantha L.C. Leach

Overview of attention for article published in BMC Complementary and Alternative Medicine, August 2015
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2 tweeters

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42 Mendeley
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Title
Structural elucidation of some antimicrobial constituents from the leaf latex of Aloe trigonantha L.C. Leach
Published in
BMC Complementary and Alternative Medicine, August 2015
DOI 10.1186/s12906-015-0803-4
Pubmed ID
Authors

Mekdes Megeressa, Daniel Bisrat, Avijit Mazumder, Kaleab Asres

Abstract

The incidents of drug resistant microorganisms and the need of treatments for newly emerging pathogens are of great concern to the global community. Our ability to treat infectious diseases is dependent on the development of new pharmaceuticals, and one potential source being medicinal plants with traditional claims. The leaves of Aloe trigonantha L.C. Leach, an endemic Ethiopian plant, are locally used for the treatment of infectious and inflammatory diseases. This study explores the potential of the latex of this plant and compounds isolated thereof for their in vitro antibacterial and antifungal properties. Analytical RP-HPLC and silica gel preparative TLC were used for identification and isolation of active constituents, respectively. Characterization of the compounds was based on UV, IR, HR-ESIMS, (1)H and (13)C NMR, and 2D-NMR spectral assignments. Antimicrobial activity studies were carried out against 21 pathogenic bacterial and 4 fungal strains using the disk diffusion method. Minimum inhibitory concentrations (MICs) were determined by the broth dilution method. A C-glycosylated chromone identified as aloesin, and three C-glycosylated anthrones characterized as 8-O-methy-7-hydroxyaloin A/B, aloin A/B and aloin-6'-O-acetate A/B were isolated. The latex and isolated compounds exhibited in vitro antibacterial activity against the tested pathogens. In some cases the activity of the isolated compounds (MIC = 10 μg/mL) was comparable with that of the standard drug ciprofloxacin, particularly against some of the Gram-negative bacterial strains tested. However, their activity towards the fungal pathogens tested was relatively weaker showing maximum activity against Candida albicans with MIC value of 400 μg/mL. The present findings can be used for further research aimed at the development of new antibacterial agents, and may also justify the ethnomedicinal claim of the plant for the treatment of infectious diseases.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 42 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 19%
Student > Ph. D. Student 5 12%
Student > Bachelor 4 10%
Lecturer 4 10%
Researcher 3 7%
Other 8 19%
Unknown 10 24%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 7 17%
Medicine and Dentistry 6 14%
Chemistry 6 14%
Biochemistry, Genetics and Molecular Biology 4 10%
Agricultural and Biological Sciences 4 10%
Other 4 10%
Unknown 11 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 February 2016.
All research outputs
#3,533,939
of 7,084,078 outputs
Outputs from BMC Complementary and Alternative Medicine
#1,024
of 1,787 outputs
Outputs of similar age
#116,823
of 224,614 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#45
of 82 outputs
Altmetric has tracked 7,084,078 research outputs across all sources so far. This one is in the 28th percentile – i.e., 28% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,787 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 224,614 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.