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Characteristics of the first metatarsophalangeal joint in gout and asymptomatic hyperuricaemia: a cross‐sectional observational study

Overview of attention for article published in Journal of Foot and Ankle Research, August 2015
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Title
Characteristics of the first metatarsophalangeal joint in gout and asymptomatic hyperuricaemia: a cross‐sectional observational study
Published in
Journal of Foot and Ankle Research, August 2015
DOI 10.1186/s13047-015-0091-8
Pubmed ID
Authors

Sarah Stewart, Nicola Dalbeth, Alain C. Vandal, Keith Rome

Abstract

This study aimed to identify patient-reported outcomes and clinician-assessed characteristics of the first metatarsophalangeal joint (1MTPJ) in people with gout and with asymptomatic hyperuricaemia by comparing them to normouricaemic controls. Twenty four people with gout (without current symptoms of acute arthritis), 29 with asymptomatic hyperuricaemia and 34 age- and sex-matched controls participated in this cross-sectional observational study. Patient-reported outcomes included 1MTPJ pain, foot pain and disability, body pain, lower limb function, activity limitation and overall wellbeing. Clinician-assessed characteristics of the 1MTPJ included range of motion (ROM), plantar- and dorsi-flexion force, foot posture, temperature and hallux valgus severity. Compared to controls, participants with gout reported greater 1MTPJ pain (p = 0.014), greater foot pain and disability (p < 0.001), increased odds of having disabling foot pain (odds ratio (OR) 13.4, p < 0.001), decreased lower limb function for daily living (p = 0.002) and recreational (p < 0.001) activities, increased activity limitation (p = 0.002), reduced overall wellbeing (p = 0.034), reduced ROM (p < 0.001), reduced plantarflexion force (p = 0.012), increased 1MTPJ plantar (p = 0.004), dorsal (p = 0.003) and medial (p = 0.004) temperature and had increased odds of having more severe hallux valgus (OR 0.3 p = 0.041). Compared to controls, participants with asymptomatic hyperuricaemia had increased odds of having disabling foot pain (OR 4.2, p = 0.013), increased activity limitation (p = 0.033), decreased lower limb function for daily living (p = 0.026) and recreational (p = 0.010) activities, increased 1MTPJ plantarflexion force (p = 0.004) and a more pronated foot type (p = 0.036). People with gout demonstrate 1MTPJ-specific changes indicative of subclinical inflammation, even in the absence of acute arthritis. People with asymptomatic hyperuricaemia, who exhibit no features or symptoms of gout, also report high levels of foot- and lower limb-related pain and disability.

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Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 13%
Student > Doctoral Student 4 10%
Other 3 8%
Lecturer 3 8%
Researcher 3 8%
Other 10 25%
Unknown 12 30%
Readers by discipline Count As %
Medicine and Dentistry 14 35%
Nursing and Health Professions 4 10%
Psychology 2 5%
Immunology and Microbiology 1 3%
Chemical Engineering 1 3%
Other 4 10%
Unknown 14 35%