Title |
Elevated faecal ovotransferrin concentrations are indicative for intestinal barrier failure in broiler chickens
|
---|---|
Published in |
Veterinary Research, June 2018
|
DOI | 10.1186/s13567-018-0548-4 |
Pubmed ID | |
Authors |
Evy Goossens, Griet Debyser, Chana Callens, Maarten De Gussem, Annelike Dedeurwaerder, Bart Devreese, Freddy Haesebrouck, Monika Flügel, Stefan Pelzer, Frank Thiemann, Richard Ducatelle, Filip Van Immerseel |
Abstract |
Intestinal health is critically important for the welfare and performance of poultry. Enteric diseases that cause gut barrier failure result in high economic losses. Up till now there is no reliable faecal marker to measure gut barrier failure under field conditions. Therefore, the aim of the present study was to identify a faecal protein marker for diminished intestinal barrier function due to enteric diseases in broilers. To assess this, experimental necrotic enteritis and coccidiosis in broilers were used as models for gut barrier failure. Ovotransferrin was identified as a marker for gut barrier failure using a proteomics approach on samples from chickens with necrotic enteritis. These results were confirmed via ELISA on samples derived from both necrotic enteritis and coccidiosis trials, where faecal ovotransferrin levels were significantly correlated with the severity of gut barrier failure caused by either coccidiosis or necrotic enteritis. This indicates that faecal ovotransferrin quantification may represent a valuable tool to measure gut barrier failure caused by enteric pathogens. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Belgium | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 57 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 11 | 19% |
Student > Ph. D. Student | 9 | 16% |
Researcher | 8 | 14% |
Student > Bachelor | 3 | 5% |
Student > Doctoral Student | 2 | 4% |
Other | 7 | 12% |
Unknown | 17 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 25% |
Veterinary Science and Veterinary Medicine | 12 | 21% |
Biochemistry, Genetics and Molecular Biology | 4 | 7% |
Immunology and Microbiology | 3 | 5% |
Nursing and Health Professions | 1 | 2% |
Other | 6 | 11% |
Unknown | 17 | 30% |