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Elevated faecal ovotransferrin concentrations are indicative for intestinal barrier failure in broiler chickens

Overview of attention for article published in Veterinary Research, June 2018
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  • Above-average Attention Score compared to outputs of the same age (63rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

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Title
Elevated faecal ovotransferrin concentrations are indicative for intestinal barrier failure in broiler chickens
Published in
Veterinary Research, June 2018
DOI 10.1186/s13567-018-0548-4
Pubmed ID
Authors

Evy Goossens, Griet Debyser, Chana Callens, Maarten De Gussem, Annelike Dedeurwaerder, Bart Devreese, Freddy Haesebrouck, Monika Flügel, Stefan Pelzer, Frank Thiemann, Richard Ducatelle, Filip Van Immerseel

Abstract

Intestinal health is critically important for the welfare and performance of poultry. Enteric diseases that cause gut barrier failure result in high economic losses. Up till now there is no reliable faecal marker to measure gut barrier failure under field conditions. Therefore, the aim of the present study was to identify a faecal protein marker for diminished intestinal barrier function due to enteric diseases in broilers. To assess this, experimental necrotic enteritis and coccidiosis in broilers were used as models for gut barrier failure. Ovotransferrin was identified as a marker for gut barrier failure using a proteomics approach on samples from chickens with necrotic enteritis. These results were confirmed via ELISA on samples derived from both necrotic enteritis and coccidiosis trials, where faecal ovotransferrin levels were significantly correlated with the severity of gut barrier failure caused by either coccidiosis or necrotic enteritis. This indicates that faecal ovotransferrin quantification may represent a valuable tool to measure gut barrier failure caused by enteric pathogens.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 57 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 19%
Student > Ph. D. Student 9 16%
Researcher 8 14%
Student > Bachelor 3 5%
Student > Doctoral Student 2 4%
Other 7 12%
Unknown 17 30%
Readers by discipline Count As %
Agricultural and Biological Sciences 14 25%
Veterinary Science and Veterinary Medicine 12 21%
Biochemistry, Genetics and Molecular Biology 4 7%
Immunology and Microbiology 3 5%
Nursing and Health Professions 1 2%
Other 6 11%
Unknown 17 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2021.
All research outputs
#7,782,070
of 25,385,509 outputs
Outputs from Veterinary Research
#356
of 1,337 outputs
Outputs of similar age
#124,492
of 341,526 outputs
Outputs of similar age from Veterinary Research
#14
of 36 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 1,337 research outputs from this source. They receive a mean Attention Score of 5.0. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,526 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.