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X Demographics
Mendeley readers
| Title |
Decaprenyl-phosphoryl-ribose 2′-epimerase (DprE1): challenging target for antitubercular drug discovery
|
|---|---|
| Published in |
BMC Chemistry, June 2018
|
| DOI | 10.1186/s13065-018-0441-2 |
| Pubmed ID | |
| Authors |
Jineetkumar Gawad, Chandrakant Bonde |
| Abstract |
Tuberculosis has proved harmful to the entire history of mankind from past several decades. Decaprenyl-phosphoryl-ribose 2'-epimerase (DprE1) is a recent target which was identified in 2009 but unfortunately it is neither explored nor crossed phase II. In past several decades few targets were identified for effective antitubercular drug discovery. Resistance is the major problem for effective antitubercular drug discovery. Arabinose is constituent of mycobacterium cell wall. Biosynthesis of arabinose is FAD dependant two step epimerisation reaction which is catalysed by DprE1 and DprE2 flavoprotein enzymes. The current review is mainly emphases on DprE1 as a perspective challenge for further research. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 75 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 17% |
| Student > Master | 8 | 11% |
| Student > Bachelor | 8 | 11% |
| Researcher | 6 | 8% |
| Other | 3 | 4% |
| Other | 9 | 12% |
| Unknown | 28 | 37% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 19% |
| Chemistry | 13 | 17% |
| Biochemistry, Genetics and Molecular Biology | 8 | 11% |
| Engineering | 3 | 4% |
| Medicine and Dentistry | 3 | 4% |
| Other | 5 | 7% |
| Unknown | 29 | 39% |