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Antibiotic resistance of Streptococcus agalactiae isolated from pregnant women in Garankuwa, South Africa

Overview of attention for article published in BMC Research Notes, August 2015
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Title
Antibiotic resistance of Streptococcus agalactiae isolated from pregnant women in Garankuwa, South Africa
Published in
BMC Research Notes, August 2015
DOI 10.1186/s13104-015-1328-0
Pubmed ID
Authors

John Y. Bolukaoto, Charles M. Monyama, Martina O. Chukwu, Sebotse M. Lekala, Maphoshane Nchabeleng, Motlatji R. B. Maloba, Rooyen T. Mavenyengwa, Sogolo L. Lebelo, Sam T. Monokoane, Charles Tshepuwane, Sylvester R. Moyo

Abstract

This study was undertaken to determine the susceptibility profile and the mechanism of antibiotic resistance in Group B streptococcus (GBS) isolates detected in vaginal and rectal swabs from pregnant women attending Dr George Mukhari Academic Hospital, a University Teaching Hospital in Pretoria, South Africa. The samples were collected over an 11-month period, cultured on selective media (colistin and nalidixic acid agar and Todd-Hewitt broth), and GBS positively identified by using different morphological and biochemical tests. The susceptibility testing was done using the Kirby-Bauer and E test methods according to CLSI guidelines 2012. The D test method was used for the detection of inducible clindamycin resistance. Multiplex PCR with specific primers was used to detect different genes coding for resistance. Out of 413 samples collected, 128 (30.9 %) were positive with GBS. The susceptibility testing revealed that 100 % of isolates were sensitive to penicillin, ampicillin, vancomycin and high level gentamicin. Erythromycin and clindamycin resistance was 21.1 and 17.2 %, respectively, in which 69 % had harboured constitutive macrolide, lincosamide and streptogramin B (MLSB), 17.4 % had inducible MLSB. The M and L phenotypes were present in 6.8 % each. The methylation of target encoded by ermB genes was the commonest mechanism of resistance observed in 55 % of isolates, 38 % of isolates had both ermB and linB genes and efflux pump mediated by mefA genes was also distributed among the isolates. The study reaffirmed the appropriateness of penicillin as the antibiotic of choice for treating GBS infection. However it identified the challenges of resistance to macrolides and lincosamides used as alternative drugs for individuals allergic to penicillin. More GBS treatment options for penicillin allergic patients need to be researched on.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 141 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 141 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 23 16%
Student > Bachelor 22 16%
Student > Ph. D. Student 21 15%
Researcher 13 9%
Student > Postgraduate 10 7%
Other 23 16%
Unknown 29 21%
Readers by discipline Count As %
Medicine and Dentistry 30 21%
Agricultural and Biological Sciences 23 16%
Biochemistry, Genetics and Molecular Biology 15 11%
Immunology and Microbiology 13 9%
Nursing and Health Professions 6 4%
Other 23 16%
Unknown 31 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 August 2015.
All research outputs
#4,642,314
of 5,568,281 outputs
Outputs from BMC Research Notes
#1,406
of 1,742 outputs
Outputs of similar age
#154,236
of 192,579 outputs
Outputs of similar age from BMC Research Notes
#96
of 131 outputs
Altmetric has tracked 5,568,281 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,742 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 131 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.