Title |
Oral Candida albicans isolates from HIV-positive individuals have similar in vitro biofilm-forming ability and pathogenicity as invasive Candida isolates
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Published in |
BMC Microbiology, November 2011
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DOI | 10.1186/1471-2180-11-247 |
Pubmed ID | |
Authors |
Juliana C Junqueira, Beth B Fuchs, Maged Muhammed, Jeffrey J Coleman, Jamal MAH Suleiman, Simone FG Vilela, Anna CBP Costa, Vanessa MC Rasteiro, Antonio OC Jorge, Eleftherios Mylonakis |
Abstract |
Candida can cause mucocutaneous and/or systemic infections in hospitalized and immunosuppressed patients. Most individuals are colonized by Candida spp. as part of the oral flora and the intestinal tract. We compared oral and systemic isolates for the capacity to form biofilm in an in vitro biofilm model and pathogenicity in the Galleria mellonella infection model. The oral Candida strains were isolated from the HIV patients and included species of C. albicans, C. glabrata, C. tropicalis, C. parapsilosis, C. krusei, C. norvegensis, and C. dubliniensis. The systemic strains were isolated from patients with invasive candidiasis and included species of C. albicans, C. glabrata, C. tropicalis, C. parapsilosis, C. lusitaniae, and C. kefyr. For each of the acquired strains, biofilm formation was evaluated on standardized samples of silicone pads and acrylic resin. We assessed the pathogenicity of the strains by infecting G. mellonella animals with Candida strains and observing survival. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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India | 1 | 1% |
Denmark | 1 | 1% |
Unknown | 86 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 12 | 14% |
Student > Ph. D. Student | 10 | 11% |
Student > Bachelor | 9 | 10% |
Researcher | 8 | 9% |
Professor | 7 | 8% |
Other | 21 | 24% |
Unknown | 21 | 24% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 26 | 30% |
Agricultural and Biological Sciences | 17 | 19% |
Biochemistry, Genetics and Molecular Biology | 8 | 9% |
Immunology and Microbiology | 8 | 9% |
Business, Management and Accounting | 1 | 1% |
Other | 5 | 6% |
Unknown | 23 | 26% |