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Recombinant E2 protein enhances protective efficacy of inactivated bovine viral diarrhea virus 2 vaccine in a goat model

Overview of attention for article published in BMC Veterinary Research, June 2018
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1 tweeter

Citations

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4 Dimensions

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21 Mendeley
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Title
Recombinant E2 protein enhances protective efficacy of inactivated bovine viral diarrhea virus 2 vaccine in a goat model
Published in
BMC Veterinary Research, June 2018
DOI 10.1186/s12917-018-1520-2
Pubmed ID
Authors

Yao-Chi Chung, Li-Ting Cheng, Jia-Yu Zhang, Yue-Jyun Wu, Shyh-Shyan Liu, Chun-Yen Chu

Abstract

Inactivated and subunit bovine viral diarrhea virus (BVDV) vaccines have shown limited protective efficacy. This study aimed to evaluate the effectiveness of a vaccine containing both inactivated BVDV (iBVDV) and baculovirus-expressed recombinant E2 (rE2), an important BVDV antigen with strongly neutralizing epitopes. Four groups of goats were immunized twice with one of four vaccine preparations: 1) iBVDV+rE2, 2) rE2, 3) iBVDV, and 4) saline, and challenged with BVDV. For goats vaccinated with the iBVDV+rE2 vaccine, no viremia was observed after challenge, and clinical signs, pyrexia, and leukopenia were reduced compared to the saline group. In contrast, for goats vaccinated with either iBVDV or rE2 alone, viremia was still detectable. The combination of iBVDV and rE2 elicited stronger protective immune responses against BVDV than iBVDV or rE2 alone.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 24%
Student > Master 3 14%
Student > Ph. D. Student 3 14%
Professor > Associate Professor 2 10%
Lecturer 1 5%
Other 2 10%
Unknown 5 24%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 5 24%
Biochemistry, Genetics and Molecular Biology 3 14%
Agricultural and Biological Sciences 2 10%
Immunology and Microbiology 1 5%
Chemistry 1 5%
Other 0 0%
Unknown 9 43%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2018.
All research outputs
#11,674,220
of 13,145,206 outputs
Outputs from BMC Veterinary Research
#1,530
of 1,900 outputs
Outputs of similar age
#232,661
of 268,718 outputs
Outputs of similar age from BMC Veterinary Research
#14
of 17 outputs
Altmetric has tracked 13,145,206 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,900 research outputs from this source. They receive a mean Attention Score of 2.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,718 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.