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A rapid field test for the measurement of bovine serum immunoglobulin G using attenuated total reflectance infrared spectroscopy

Overview of attention for article published in BMC Veterinary Research, August 2015
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  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

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Title
A rapid field test for the measurement of bovine serum immunoglobulin G using attenuated total reflectance infrared spectroscopy
Published in
BMC Veterinary Research, August 2015
DOI 10.1186/s12917-015-0539-x
Pubmed ID
Authors

Ibrahim Elsohaby, Siyuan Hou, J. Trenton McClure, Christopher B. Riley, R. Anthony Shaw, Gregory P. Keefe

Abstract

Following the recent development of a new approach to quantitative analysis of IgG concentrations in bovine serum using transmission infrared spectroscopy, the potential to measure IgG levels using technology and a device better designed for field use was investigated. A method using attenuated total reflectance infrared (ATR) spectroscopy in combination with partial least squares (PLS) regression was developed to measure bovine serum IgG concentrations. ATR spectroscopy has a distinct ease-of-use advantage that may open the door to routine point-of-care testing. Serum samples were collected from calves and adult cows, tested by a reference RID method, and ATR spectra acquired. The spectra were linked to the RID-IgG concentrations and then randomly split into two sets: calibration and prediction. The calibration set was used to build a calibration model, while the prediction set was used to assess the predictive performance and accuracy of the final model. The procedure was repeated for various spectral data preprocessing approaches. For the prediction set, the Pearson's and concordance correlation coefficients between the IgG measured by RID and predicted by ATR spectroscopy were both 0.93. The Bland Altman plot revealed no obvious systematic bias between the two methods. ATR spectroscopy showed a sensitivity for detection of failure of transfer of passive immunity (FTPI) of 88 %, specificity of 100 % and accuracy of 94 % (with IgG <1000 mg/dL as the FTPI cut-off value). ATR spectroscopy in combination with multivariate data analysis shows potential as an alternative approach for rapid quantification of IgG concentrations in bovine serum and the diagnosis of FTPI in calves.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 23%
Professor 3 10%
Student > Bachelor 2 7%
Lecturer 2 7%
Professor > Associate Professor 2 7%
Other 5 17%
Unknown 9 30%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 8 27%
Agricultural and Biological Sciences 6 20%
Medicine and Dentistry 3 10%
Engineering 2 7%
Materials Science 1 3%
Other 1 3%
Unknown 9 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2020.
All research outputs
#14,235,639
of 22,824,164 outputs
Outputs from BMC Veterinary Research
#1,110
of 3,050 outputs
Outputs of similar age
#137,634
of 265,958 outputs
Outputs of similar age from BMC Veterinary Research
#27
of 72 outputs
Altmetric has tracked 22,824,164 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,050 research outputs from this source. They receive a mean Attention Score of 3.8. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,958 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.