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Point of care susceptibility testing in primary care - does it lead to a more appropriate prescription of antibiotics in patients with uncomplicated urinary tract infections? Protocol for a…

Overview of attention for article published in BMC Family Practice, August 2015
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1 tweeter

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Title
Point of care susceptibility testing in primary care - does it lead to a more appropriate prescription of antibiotics in patients with uncomplicated urinary tract infections? Protocol for a randomized controlled trial
Published in
BMC Family Practice, August 2015
DOI 10.1186/s12875-015-0322-x
Pubmed ID
Authors

Anne Holm, Gloria Cordoba, Tina Møller Sørensen, Lisbeth Rem Jessen, Volkert Siersma, Lars Bjerrum

Abstract

Urinary tract infection (UTI) is a common infection in primary care and is the second leading reason for prescription of antibiotics in Denmark. The diagnosis is often based on symptoms and urine dip-stick, which has limited validity, causing the risk of unnecessary antibiotic prescription. Additionally, with increasing antibiotic resistance, the risk of choosing an antibiotic to which an infecting pathogen is resistant is rising. Combined point-of-care-tests (POCT) for urine culture and susceptibility testing have been developed and validated for primary care, and performing such a test in all patients with suspected UTI in primary care seems rational in order to reduce the use of inappropriate antibiotics. However, the clinical effect of the culture and susceptibility test has not yet been investigated. This study aims to investigate whether POCT urine culture and susceptibility testing decreases the inappropriate use of antibiotics and leads to faster patient recovery. Randomized controlled open label trial of two diagnostic approaches. 750 patients with symptoms of uncomplicated UTI, consecutively contacting their general practitioner (GP), randomized to either POCT urine culture and susceptibility testing and targeted treatment or POCT urine culture without susceptibility testing and empirical treatment. Treatment is started when the POCT is read. The two groups are compared with regard to appropriate choice of antibiotics, clinical remission, and microbiological cure rates. The results of this study may provide important evidence to recommend POCT culture and susceptibility testing in all patients with suspected uncomplicated UTI. This could become an additional strategy to fight antibiotic resistance. ClinicalTrials.gov NCT02323087 .

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 75 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 75 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 13 17%
Student > Master 12 16%
Student > Ph. D. Student 9 12%
Researcher 7 9%
Student > Doctoral Student 4 5%
Other 14 19%
Unknown 16 21%
Readers by discipline Count As %
Medicine and Dentistry 22 29%
Biochemistry, Genetics and Molecular Biology 6 8%
Immunology and Microbiology 6 8%
Pharmacology, Toxicology and Pharmaceutical Science 5 7%
Veterinary Science and Veterinary Medicine 3 4%
Other 12 16%
Unknown 21 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 August 2015.
All research outputs
#4,644,306
of 5,570,954 outputs
Outputs from BMC Family Practice
#810
of 874 outputs
Outputs of similar age
#154,362
of 192,697 outputs
Outputs of similar age from BMC Family Practice
#42
of 43 outputs
Altmetric has tracked 5,570,954 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
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