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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Stool microbiota composition is associated with the prospective risk of Plasmodium falciparum infection
|
|---|---|
| Published in |
BMC Genomics, August 2015
|
| DOI | 10.1186/s12864-015-1819-3 |
| Pubmed ID | |
| Authors |
Shibu Yooseph, Ewen F. Kirkness, Tuan M. Tran, Derek M. Harkins, Marcus B. Jones, Manolito G. Torralba, Elise O’Connell, Thomas B. Nutman, Safiatou Doumbo, Ogobara K. Doumbo, Boubacar Traore, Peter D. Crompton, Karen E. Nelson |
| Abstract |
In humans it is unknown if the composition of the gut microbiota alters the risk of Plasmodium falciparum infection or the risk of developing febrile malaria once P. falciparum infection is established. Here we collected stool samples from a cohort composed of 195 Malian children and adults just prior to an intense P. falciparum transmission season. We assayed these samples using massively parallel sequencing of the 16S ribosomal RNA gene to identify the composition of the gut bacterial communities in these individuals. During the ensuing 6-month P. falciparum transmission season we examined the relationship between the stool microbiota composition of individuals in this cohort and their prospective risk of both P. falciparum infection and febrile malaria. Consistent with prior studies, stool microbial diversity in the present cohort increased with age, although the overall microbiota profile was distinct from cohorts in other regions of Africa, Asia and North America. Age-adjusted Cox regression analysis revealed a significant association between microbiota composition and the prospective risk of P. falciparum infection; however, no relationship was observed between microbiota composition and the risk of developing febrile malaria once P. falciparum infection was established. These findings underscore the diversity of gut microbiota across geographic regions, and suggest that strategic modulation of gut microbiota composition could decrease the risk of P. falciparum infection in malaria-endemic areas, potentially as an adjunct to partially effective malaria vaccines. |
X Demographics
The data shown below were collected from the profiles of 18 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 17% |
| United Kingdom | 2 | 11% |
| Japan | 1 | 6% |
| Germany | 1 | 6% |
| Canada | 1 | 6% |
| Ireland | 1 | 6% |
| Guatemala | 1 | 6% |
| France | 1 | 6% |
| Unknown | 7 | 39% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 13 | 72% |
| Scientists | 3 | 17% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
| Practitioners (doctors, other healthcare professionals) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 188 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| India | 1 | <1% |
| Unknown | 186 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 38 | 20% |
| Researcher | 32 | 17% |
| Student > Master | 23 | 12% |
| Student > Bachelor | 16 | 9% |
| Student > Doctoral Student | 9 | 5% |
| Other | 25 | 13% |
| Unknown | 45 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 35 | 19% |
| Medicine and Dentistry | 26 | 14% |
| Immunology and Microbiology | 25 | 13% |
| Biochemistry, Genetics and Molecular Biology | 23 | 12% |
| Nursing and Health Professions | 5 | 3% |
| Other | 22 | 12% |
| Unknown | 52 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 August 2015.
All research outputs
#4,152,128
of 25,517,918 outputs
Outputs from BMC Genomics
#1,467
of 11,274 outputs
Outputs of similar age
#49,446
of 277,930 outputs
Outputs of similar age from BMC Genomics
#33
of 261 outputs
Altmetric has tracked 25,517,918 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,274 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,930 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 261 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.