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Anti-CD20 B-cell depletion enhances monocyte reactivity in neuroimmunological disorders

Overview of attention for article published in Journal of Neuroinflammation, October 2011
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

Mentioned by

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1 patent
facebook
1 Facebook page

Citations

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65 Dimensions

Readers on

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92 Mendeley
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Title
Anti-CD20 B-cell depletion enhances monocyte reactivity in neuroimmunological disorders
Published in
Journal of Neuroinflammation, October 2011
DOI 10.1186/1742-2094-8-146
Pubmed ID
Authors

Klaus Lehmann-Horn, Eva Schleich, Deetje Hertzenberg, Alexander Hapfelmeier, Tania Kümpfel, Nikolas von Bubnoff, Reinhard Hohlfeld, Achim Berthele, Bernhard Hemmer, Martin S Weber

Abstract

Clinical trials evaluating anti-CD20-mediated B-cell depletion in multiple sclerosis (MS) and neuromyelitis optica (NMO) generated encouraging results. Our recent studies in the MS model experimental autoimmune encephalomyelitis (EAE) attributed clinical benefit to extinction of activated B-cells, but cautioned that depletion of naïve B-cells may be undesirable. We elucidated the regulatory role of un-activated B-cells in EAE and investigated whether anti-CD20 may collaterally diminish regulatory B-cell properties in treatment of neuroimmunological disorders.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 1 1%
Unknown 91 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 20%
Researcher 16 17%
Student > Bachelor 9 10%
Student > Master 7 8%
Student > Postgraduate 6 7%
Other 15 16%
Unknown 21 23%
Readers by discipline Count As %
Medicine and Dentistry 23 25%
Neuroscience 15 16%
Agricultural and Biological Sciences 10 11%
Biochemistry, Genetics and Molecular Biology 8 9%
Immunology and Microbiology 4 4%
Other 8 9%
Unknown 24 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2020.
All research outputs
#7,167,416
of 22,656,971 outputs
Outputs from Journal of Neuroinflammation
#1,175
of 2,601 outputs
Outputs of similar age
#45,253
of 140,468 outputs
Outputs of similar age from Journal of Neuroinflammation
#5
of 20 outputs
Altmetric has tracked 22,656,971 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 2,601 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 140,468 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.