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The effect of citrate dialysate on intradialytic heparin dose in haemodialysis patients: study design of a randomised controlled trial

Overview of attention for article published in BMC Nephrology, August 2015
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Title
The effect of citrate dialysate on intradialytic heparin dose in haemodialysis patients: study design of a randomised controlled trial
Published in
BMC Nephrology, August 2015
DOI 10.1186/s12882-015-0144-z
Pubmed ID
Authors

Davina J. Tai, Kelvin Leung, Pietro Ravani, Robert R. Quinn, Nairne Scott-Douglas, Jennifer M. MacRae

Abstract

Unfractionated heparin is the most common anticoagulant used in haemodialysis (HD), although it has many potential adverse effects. Citrate dialysate (CD) has an anticoagulant effect which may allow reduction in cumulative heparin dose (CHD) compared to standard acetate dialysate (AD). This double-blinded, randomised, cross-over trial of chronic haemodialysis patients determines if CD allows reduction in CHD during HD compared with AD. After enrolment, intradialytic heparin is minimised during a two-week run-in period using a standardised protocol based on a visual clotting score. Patients still requiring intradialytic heparin after the run-in period are randomised to two weeks of HD with AD followed by two weeks of CD (Sequence 1) or two weeks of HD with CD followed by two weeks of AD (Sequence 2). The primary outcome is the change in CHD with CD compared with AD. Secondary outcomes include metabolic and haemodynamic parameters, and dialysis adequacy. This randomised controlled trial will determine the impact of CD compared with AD on CHD during HD. ClinicalTrials.gov NCT01466959.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 29%
Student > Postgraduate 6 21%
Other 3 11%
Researcher 3 11%
Student > Ph. D. Student 1 4%
Other 3 11%
Unknown 4 14%
Readers by discipline Count As %
Medicine and Dentistry 11 39%
Biochemistry, Genetics and Molecular Biology 3 11%
Nursing and Health Professions 2 7%
Engineering 2 7%
Economics, Econometrics and Finance 1 4%
Other 5 18%
Unknown 4 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 August 2015.
All research outputs
#18,425,370
of 22,826,360 outputs
Outputs from BMC Nephrology
#1,873
of 2,469 outputs
Outputs of similar age
#193,070
of 267,539 outputs
Outputs of similar age from BMC Nephrology
#29
of 34 outputs
Altmetric has tracked 22,826,360 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,469 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 11th percentile – i.e., 11% of its peers scored the same or lower than it.
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We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.