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Study of the protective effect on intestinal mucosa of the hydrosoluble fiber Plantago ovata husk

Overview of attention for article published in BMC Complementary Medicine and Therapies, August 2015
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Title
Study of the protective effect on intestinal mucosa of the hydrosoluble fiber Plantago ovata husk
Published in
BMC Complementary Medicine and Therapies, August 2015
DOI 10.1186/s12906-015-0827-9
Pubmed ID
Authors

Ana M. Sahagún, José Vaquera, Juan J. García, Ángela P. Calle, María-José Diez, Nélida Fernández, Juan F. Loro, Hugo O. Portilla, Matilde Sierra

Abstract

Several studies have indicated that dietary fiber may have a protective effect on gastrointestinal mucosa. The aim of this study was to evaluate the protective action of the soluble fiber Plantago ovata husk against intestinal damage. To evaluate the anti-ulcerogenic effect on duodenal mucosa of the soluble fiber Plantago ovata husk, low-dose acetylsalicylic acid (10 mg/kg) was given orally to animals once daily for 14 or 28 days with and without Plantago ovata husk (100 mg/kg). 24 h after final dosing duodenal samples were removed for anatomopathological evaluation. Villi were examined by both light and scanning electron microscopy. Acetylsalicylic acid induced severe lesions in duodenal mucosa of rabbits, including erosions, epithelium disorganization, and cell vacuolization, increasing as well the amount of mononuclear and caliciform cells. Damage was much more severe in animals treated for 28 days. In groups receiving Plantago ovata husk, a significant attenuation of acetylsalicylic acid-induced lesions was already observed in group treated for 14 days, becoming more evident in those treated for 28 days, all of them with duodenal cytoarchitecture normal and similar to control animals. These findings suggest that Plantago ovata husk may protect intestinal mucosa probably by limiting acetylsalicylic acid penetration into epithelial cells, although further studies are needed to confirm the same effect in other experimental models of induced mucosal damage and to elucidate the mechanisms of fiber protection.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Australia 1 3%
Unknown 34 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 23%
Professor 6 17%
Student > Master 5 14%
Student > Ph. D. Student 3 9%
Other 2 6%
Other 4 11%
Unknown 7 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 20%
Medicine and Dentistry 6 17%
Nursing and Health Professions 4 11%
Pharmacology, Toxicology and Pharmaceutical Science 3 9%
Biochemistry, Genetics and Molecular Biology 2 6%
Other 4 11%
Unknown 9 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2015.
All research outputs
#20,290,425
of 22,826,360 outputs
Outputs from BMC Complementary Medicine and Therapies
#2,978
of 3,631 outputs
Outputs of similar age
#224,086
of 266,764 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#67
of 82 outputs
Altmetric has tracked 22,826,360 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,631 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,764 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.