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Pharmaceutical/food grade titanium dioxide particles are absorbed into the bloodstream of human volunteers

Overview of attention for article published in Particle and Fibre Toxicology, September 2015
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  • Good Attention Score compared to outputs of the same age (73rd percentile)

Mentioned by

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6 tweeters

Citations

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95 Dimensions

Readers on

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68 Mendeley
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Title
Pharmaceutical/food grade titanium dioxide particles are absorbed into the bloodstream of human volunteers
Published in
Particle and Fibre Toxicology, September 2015
DOI 10.1186/s12989-015-0101-9
Pubmed ID
Authors

Laetitia C. Pele, Vinay Thoree, Sylvaine FA Bruggraber, Dagmar Koller, Richard PH Thompson, Miranda C. Lomer, Jonathan J. Powell

Abstract

Exposure to persistent engineered nano and micro particles via the oral route is well established. Animal studies have demonstrated that, once ingested, a small proportion of such particles translocate from the gastrointestinal tract to other tissues. Exposure to titanium dioxide is widespread via the oral route, but only one study has provided indirect evidence (total titanium analyses) of absorption into the blood stream in humans. We sought to replicate these observations and to provide additional evidence for particulate uptake. Human volunteers with normal intestinal permeability were orally administered 100 mg pharmaceutical/food grade titanium dioxide. Blood samples were collected from 0.5 to 10 h post ingestion and analysed for the presence of reflectant bodies (particles) by dark field microscopy, and for total titanium by inductively coupled plasma mass spectrometry (ICP-MS). Blood film analyses implied early absorption of particles (2 h) with a peak maximum at 6 h following ingestion. The presence of these reflectant particles in blood roughly mirrored the levels of total titanium by ICP-MS, providing good evidence for the latter being a measure of whole particle (titanium dioxide) absorption. This study shows that a fraction of pharmaceutical/food grade titanium dioxide is absorbed systemically by humans following ingestion. It confirms that at least two routes of particle uptake may exist in the human gut- one proximal and one distal. Further work should quantify human exposure and uptake of such persistent particles.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 68 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 1%
Unknown 67 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 18%
Student > Ph. D. Student 11 16%
Student > Master 10 15%
Student > Bachelor 6 9%
Student > Doctoral Student 5 7%
Other 12 18%
Unknown 12 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 18%
Chemistry 11 16%
Biochemistry, Genetics and Molecular Biology 11 16%
Medicine and Dentistry 3 4%
Pharmacology, Toxicology and Pharmaceutical Science 2 3%
Other 9 13%
Unknown 20 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 July 2017.
All research outputs
#4,117,839
of 15,248,491 outputs
Outputs from Particle and Fibre Toxicology
#138
of 450 outputs
Outputs of similar age
#63,883
of 240,743 outputs
Outputs of similar age from Particle and Fibre Toxicology
#1
of 1 outputs
Altmetric has tracked 15,248,491 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 450 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,743 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them