Title |
A case of HER-2-positive recurrent breast cancer showing a clinically complete response to trastuzumab-containing chemotherapy after primary treatment of triple-negative breast cancer
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Published in |
World Journal of Surgical Oncology, November 2011
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DOI | 10.1186/1477-7819-9-146 |
Pubmed ID | |
Authors |
Hideo Shigematsu, Takayuki Kadoya, Yoshie Kobayashi, Keiko Kajitani, Tatsunari Sasada, Akiko Emi, Norio Masumoto, Rumi Haruta, Tsuyoshi Kataoka, Miyo Oda, Kouji Arihiro, Morihito Okada |
Abstract |
We report a case of HER-2-positive recurrent breast cancer showing a clinically complete response to trastuzumab-containing chemotherapy 6 years after primary treatment of triple-negative breast cancer. The primary tumor was negative for HER-2 as determined by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) (1+, and ratio, 1.1), but examination of the recurrent lymph node metastasis showed positivity for HER-2 by FISH (ratio, 5.2). No lesions were detected in either her left breast or in other organs, and the patient was diagnosed as having HER-2-positive recurrent disease. Combination chemotherapy using weekly paclitaxel and trastuzumab was initiated, and a clinically complete response was achieved. This report suggests the benefit of routine evaluation of HER-2 status in recurrent breast cancer with the introduction of HER-2-targeting agents. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 4 | 20% |
Student > Postgraduate | 3 | 15% |
Other | 2 | 10% |
Student > Master | 2 | 10% |
Researcher | 2 | 10% |
Other | 2 | 10% |
Unknown | 5 | 25% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 7 | 35% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Nursing and Health Professions | 1 | 5% |
Unspecified | 1 | 5% |
Economics, Econometrics and Finance | 1 | 5% |
Other | 3 | 15% |
Unknown | 6 | 30% |