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X Demographics
Mendeley readers
Attention Score in Context
| Title |
T cell senescence and CAR-T cell exhaustion in hematological malignancies
|
|---|---|
| Published in |
Journal of Hematology & Oncology, July 2018
|
| DOI | 10.1186/s13045-018-0629-x |
| Pubmed ID | |
| Authors |
Dimitri Kasakovski, Ling Xu, Yangqiu Li |
| Abstract |
T cell senescence has been recognized to play an immunosuppressive role in the aging population and cancer patients. Strategies dedicated to preventing or reversing replicative and premature T cell senescence are required to increase the lifespan of human beings and to reduce the morbidity from cancer. In addition, overcoming the T cell terminal differentiation or senescence from lymphoma and leukemia patients is a promising approach to enhance the effectiveness of adoptive cellular immunotherapy (ACT). Chimeric antigen receptor T (CAR-T) cell and T cell receptor-engineered T (TCR-T) cell therapy highly rely on functionally active T cells. However, the mechanisms which drive T cell senescence remain unclear and controversial. In this review, we describe recent progress for restoration of T cell homeostasis from age-related senescence as well as recovery of T cell activation in hematological malignancies. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 20% |
| Comoros | 1 | 10% |
| Russia | 1 | 10% |
| China | 1 | 10% |
| Spain | 1 | 10% |
| Unknown | 4 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 80% |
| Science communicators (journalists, bloggers, editors) | 1 | 10% |
| Scientists | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 289 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 289 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 47 | 16% |
| Student > Ph. D. Student | 42 | 15% |
| Student > Master | 34 | 12% |
| Student > Bachelor | 30 | 10% |
| Student > Doctoral Student | 17 | 6% |
| Other | 39 | 13% |
| Unknown | 80 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 63 | 22% |
| Immunology and Microbiology | 40 | 14% |
| Medicine and Dentistry | 31 | 11% |
| Agricultural and Biological Sciences | 24 | 8% |
| Engineering | 11 | 4% |
| Other | 31 | 11% |
| Unknown | 89 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 October 2021.
All research outputs
#1,850,391
of 23,907,431 outputs
Outputs from Journal of Hematology & Oncology
#137
of 1,232 outputs
Outputs of similar age
#39,707
of 330,888 outputs
Outputs of similar age from Journal of Hematology & Oncology
#5
of 23 outputs
Altmetric has tracked 23,907,431 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,232 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.4. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,888 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.