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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Epidermal growth factor enhances osteogenic differentiation of dental pulp stem cells in vitro
|
|---|---|
| Published in |
Head & Face Medicine, September 2015
|
| DOI | 10.1186/s13005-015-0086-5 |
| Pubmed ID | |
| Authors |
Casiano Del Angel-Mosqueda, Yolanda Gutiérrez-Puente, Ada Pricila López-Lozano, Ricardo Emmanuel Romero-Zavaleta, Andrés Mendiola-Jiménez, Carlos Eduardo Medina-De la Garza, Marcela Márquez-M, Myriam Angélica De la Garza-Ramos |
| Abstract |
Epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) play an important role in extracellular matrix mineralization, a complex process required for proper bone regeneration, one of the biggest challenges in dentistry. The purpose of this study was to evaluate the osteogenic potential of EGF and bFGF on dental pulp stem cells (DPSCs). Human DPSCs were isolated using CD105 magnetic microbeads and characterized by flow cytometry. To induce osteoblast differentiation, the cells were cultured in osteogenic medium supplemented with EGF or bFGF at a low concentration. Cell morphology and expression of CD146 and CD10 surface markers were analyzed using fluorescence microscopy. To measure mineralization, an alizarin red S assay was performed and typical markers of osteoblastic phenotype were evaluated by RT-PCR. EGF treatment induced morphological changes and suppression of CD146 and CD10 markers. Additionally, the cells were capable of producing calcium deposits and increasing the mRNA expression to alkaline phosphatase (ALP) and osteocalcin (OCN) in relation to control groups (p < 0.001). However, bFGF treatment showed an inhibitory effect. These data suggests that DPSCs in combination with EGF could be an effective stem cell-based therapy for bone tissue engineering applications in periodontics and oral implantology. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 1% |
| Colombia | 1 | 1% |
| Unknown | 93 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 16 | 17% |
| Student > Bachelor | 15 | 16% |
| Student > Ph. D. Student | 11 | 12% |
| Student > Doctoral Student | 6 | 6% |
| Researcher | 5 | 5% |
| Other | 8 | 8% |
| Unknown | 34 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 21% |
| Biochemistry, Genetics and Molecular Biology | 14 | 15% |
| Agricultural and Biological Sciences | 8 | 8% |
| Chemistry | 7 | 7% |
| Immunology and Microbiology | 2 | 2% |
| Other | 10 | 11% |
| Unknown | 34 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 February 2024.
All research outputs
#6,424,790
of 22,826,360 outputs
Outputs from Head & Face Medicine
#36
of 334 outputs
Outputs of similar age
#75,950
of 266,946 outputs
Outputs of similar age from Head & Face Medicine
#1
of 12 outputs
Altmetric has tracked 22,826,360 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 334 research outputs from this source. They receive a mean Attention Score of 2.1. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,946 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.