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Hakai reduces cell-substratum adhesion and increases epithelial cell invasion

Overview of attention for article published in BMC Cancer, November 2011
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Title
Hakai reduces cell-substratum adhesion and increases epithelial cell invasion
Published in
BMC Cancer, November 2011
DOI 10.1186/1471-2407-11-474
Pubmed ID
Authors

Teresa Rodríguez-Rigueiro, Manuel Valladares-Ayerbes, Mar Haz-Conde, Luis A Aparicio, Angélica Figueroa

Abstract

The dynamic regulation of cell-cell adhesions is crucial for developmental processes, including tissue formation, differentiation and motility. Adherens junctions are important components of the junctional complex between cells and are necessary for maintaining cell homeostasis and normal tissue architecture. E-cadherin is the prototype and best-characterized protein member of adherens junctions in mammalian epithelial cells. Regarded as a tumour suppressor, E-cadherin loss is associated with poor prognosis in carcinoma. The E3 ubiquitin-ligase Hakai was the first reported posttranslational regulator of the E-cadherin complex. Hakai specifically targetted E-cadherin for internalization and degradation and thereby lowered epithelial cell-cell contact. Hakai was also implicated in controlling proliferation, and promoted cancer-related gene expression by increasing the binding of RNA-binding protein PSF to RNAs encoding oncogenic proteins. We sought to investigate the possible implication of Hakai in cell-substratum adhesions and invasion in epithelial cells.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 29%
Student > Ph. D. Student 8 26%
Student > Master 4 13%
Student > Bachelor 3 10%
Other 2 6%
Other 3 10%
Unknown 2 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 35%
Biochemistry, Genetics and Molecular Biology 9 29%
Medicine and Dentistry 6 19%
Computer Science 1 3%
Immunology and Microbiology 1 3%
Other 1 3%
Unknown 2 6%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2011.
All research outputs
#20,150,151
of 22,656,971 outputs
Outputs from BMC Cancer
#6,478
of 8,237 outputs
Outputs of similar age
#130,009
of 141,801 outputs
Outputs of similar age from BMC Cancer
#77
of 101 outputs
Altmetric has tracked 22,656,971 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,237 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 101 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.