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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Variation at interleukin-6 receptor gene is associated to joint damage in rheumatoid arthritis
|
|---|---|
| Published in |
Arthritis Research & Therapy, September 2015
|
| DOI | 10.1186/s13075-015-0737-8 |
| Pubmed ID | |
| Authors |
Maria Lopez-Lasanta, Antonio Julià, Joan Maymó, Benjamín Fernández-Gutierrez, Inmaculada Ureña-Garnica, Francisco J. Blanco, Juan D. Cañete, Mercedes Alperi-López, Alex Olivè, Héctor Corominas, Jesus Tornero, Alba Erra, Miriam Almirall, Nuria Palau, Ana Ortiz, Gabriela Avila, Luis Rodriguez-Rodriguez, Arnald Alonso, Raül Tortosa, Isidoro Gonzalez-Alvaro, Sara Marsal |
| Abstract |
Interleukin-6 (IL-6) cytokine signaling is key in Rheumatoid Arthritis (RA) pathophysiology. Blocking IL-6 receptor (IL6R) has proven to be a highly effective treatment to prevent joint damage. This study was performed to investigate the association between the genetic variation at IL6R gene and the severity of joint damage in RA. IL6R gene tagging SNPs (n = 5) were genotyped in a discovery group of 527 RA patients from 5 different university hospitals from Spain. For each marker, a linear regression analysis was performed using an additive model and adjusting for the years of evolution of the disease, autoantibody status, gender and age. Haplotypes combining the SNPs were also estimated and tested for association with the level of joint destruction. Using an independent cohort of 705 RA patients from 6 university hospitals we performed a validation study of the SNPs associated in the discovery phase. In the discovery group we found a highly significant association between IL6R SNP rs4845618 and the level of joint destruction in RA (P = 0.0058, P corrected = 0.026), and a moderate association with SNP rs4453032 (P = 0.02, P corrected = 0.05). The resulting haplotype from both SNPs was more significantly associated with joint damage (P = 0.0037, P corrected = 0.011). Using the validation cohort, we replicated the association between the two IL-6R SNPs with the degree of joint destruction in RA (P = 0.007 and P = 0.04, meta-analysis P = 0.00011 and P = 0.0021, respectively), and the haplotype association (P = 0.0058, meta-analysis P = 6.64 e-5). Genetic variation at IL6R gene is associated with joint damage in RA. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 38 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 16% |
| Student > Ph. D. Student | 4 | 11% |
| Student > Doctoral Student | 3 | 8% |
| Other | 3 | 8% |
| Professor > Associate Professor | 3 | 8% |
| Other | 7 | 18% |
| Unknown | 12 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 26% |
| Biochemistry, Genetics and Molecular Biology | 6 | 16% |
| Immunology and Microbiology | 3 | 8% |
| Business, Management and Accounting | 1 | 3% |
| Psychology | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 14 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 September 2015.
All research outputs
#20,657,128
of 25,374,917 outputs
Outputs from Arthritis Research & Therapy
#2,906
of 3,380 outputs
Outputs of similar age
#203,662
of 277,644 outputs
Outputs of similar age from Arthritis Research & Therapy
#69
of 81 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,380 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 7th percentile – i.e., 7% of its peers scored the same or lower than it.
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