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Usefulness of positron emission tomography in the differentiation between tumor and infectious lesions in pediatric oncology: a case report

Overview of attention for article published in BMC Pediatrics, September 2015
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Title
Usefulness of positron emission tomography in the differentiation between tumor and infectious lesions in pediatric oncology: a case report
Published in
BMC Pediatrics, September 2015
DOI 10.1186/s12887-015-0427-3
Pubmed ID
Authors

Fernanda Rodrigues Tibúrcio, Karla Emília de Sá Rodrigues, Hérika Martins Mendes Vasconcelos, Débora Marques Miranda, Ana Cristina Simões e Silva

Abstract

Sometimes, in pediatric oncology, it is difficult to differentiate the relapse of primary tumor from other diagnoses such as post-ischemic lesions or fungal abscess, without performing an organ biopsy. In addition, patients frequently are not under clinical conditions to be biopsied, mainly due to febrile neutropenia. A growing number of studies has focused on the use of Positron emission tomography/computed tomography with 18 Fluorodeoxyglucose ([(18)F]FDG-PET/CT) to distinguish tumor relapse from infectious lesions in patients with febrile neutropenia. This case report describes a 6 years-old girl with febrile neutropenia during the treatment of neuroblastoma. Blood culture showed Candida sp. Abdominal ultrasonography revealed multiple unspecific hypoechoic areas of variable sizes in spleen, which might be either tumor or Candida-induced abscesses. [(18)F]FDG-PET/CT was performed to help the diagnosis and revealed small splenic lesions highly suggestive of disseminated candidiasis. Patient was then treated with systemic antifungal agent. After the recovery from febrile neutropenia, a spleen biopsy was performed, confirming the diagnosis of fungal abscess. Due to the small size of lesions, modalities such as ultrasonography, CT and magnetic nuclear resonance were not able in distinguishing tumor relapse from infectious lesions. This case provides an excellent example in which the use of [(18)F]FDG-PET/CT is valuable in helping to localize potential sites of disseminated fungal infection to be diagnosed within clinical context. [(18)F]FDG-PET /CT seems to have a role in the evaluation of pediatric patients with febrile neutropenia.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 17%
Student > Master 2 17%
Student > Ph. D. Student 2 17%
Lecturer > Senior Lecturer 1 8%
Student > Doctoral Student 1 8%
Other 1 8%
Unknown 3 25%
Readers by discipline Count As %
Medicine and Dentistry 4 33%
Nursing and Health Professions 2 17%
Social Sciences 1 8%
Immunology and Microbiology 1 8%
Unknown 4 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 September 2015.
All research outputs
#5,363,759
of 6,298,319 outputs
Outputs from BMC Pediatrics
#797
of 925 outputs
Outputs of similar age
#156,267
of 195,072 outputs
Outputs of similar age from BMC Pediatrics
#39
of 54 outputs
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We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.