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Untangling the Tauopathy for Alzheimer’s disease and parkinsonism

Overview of attention for article published in Journal of Biomedical Science, July 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#30 of 658)
  • High Attention Score compared to outputs of the same age (81st percentile)

Mentioned by

news
1 news outlet
twitter
2 tweeters

Citations

dimensions_citation
33 Dimensions

Readers on

mendeley
108 Mendeley
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Title
Untangling the Tauopathy for Alzheimer’s disease and parkinsonism
Published in
Journal of Biomedical Science, July 2018
DOI 10.1186/s12929-018-0457-x
Pubmed ID
Authors

Hui-Yun Chang, Tzu-Kang Sang, Ann-Shyn Chiang

Abstract

Tau is a microtubule-associated protein that mainly localizes to the axon to stabilize axonal microtubule structure and neuronal connectivity. Tau pathology is one of the most common proteinopathies that associates with age-dependent neurodegenerative diseases including Alzheimer's disease (AD), and various Parkinsonism. Tau protein undergoes a plethora of intra-molecular modifications and some altered forms promote the production of toxic oligomeric tau and paired helical filaments, and through which further assemble into neurofibrillary tangles, also known as tauopathy. In this review, we will discuss the recent advances of the tauopathy research, primarily focusing on its association with the early axonal manifestation of axonal transport defect, axonal mitochondrial stress, autophagic vesicle accumulation and the proceeding of axon destruction, and the pathogenic Tau spreading across the synapse. Two alternative strategies either by targeting tau protein itself or by improving the age-related physiological decline are currently racing to find the hopeful treatment for tauopathy. Undoubtedly, more studies are needed to combat this devastating condition that has already affected millions of people in our aging population.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 108 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 25 23%
Student > Ph. D. Student 19 18%
Researcher 10 9%
Student > Master 9 8%
Student > Doctoral Student 4 4%
Other 10 9%
Unknown 31 29%
Readers by discipline Count As %
Neuroscience 24 22%
Biochemistry, Genetics and Molecular Biology 22 20%
Medicine and Dentistry 8 7%
Pharmacology, Toxicology and Pharmaceutical Science 6 6%
Chemistry 4 4%
Other 13 12%
Unknown 31 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2018.
All research outputs
#1,503,634
of 13,480,923 outputs
Outputs from Journal of Biomedical Science
#30
of 658 outputs
Outputs of similar age
#49,353
of 265,689 outputs
Outputs of similar age from Journal of Biomedical Science
#1
of 1 outputs
Altmetric has tracked 13,480,923 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 658 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,689 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them