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Untangling the Tauopathy for Alzheimer’s disease and parkinsonism

Overview of attention for article published in Journal of Biomedical Science, July 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

Mentioned by

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1 news outlet
twitter
2 X users

Citations

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41 Dimensions

Readers on

mendeley
123 Mendeley
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Title
Untangling the Tauopathy for Alzheimer’s disease and parkinsonism
Published in
Journal of Biomedical Science, July 2018
DOI 10.1186/s12929-018-0457-x
Pubmed ID
Authors

Hui-Yun Chang, Tzu-Kang Sang, Ann-Shyn Chiang

Abstract

Tau is a microtubule-associated protein that mainly localizes to the axon to stabilize axonal microtubule structure and neuronal connectivity. Tau pathology is one of the most common proteinopathies that associates with age-dependent neurodegenerative diseases including Alzheimer's disease (AD), and various Parkinsonism. Tau protein undergoes a plethora of intra-molecular modifications and some altered forms promote the production of toxic oligomeric tau and paired helical filaments, and through which further assemble into neurofibrillary tangles, also known as tauopathy. In this review, we will discuss the recent advances of the tauopathy research, primarily focusing on its association with the early axonal manifestation of axonal transport defect, axonal mitochondrial stress, autophagic vesicle accumulation and the proceeding of axon destruction, and the pathogenic Tau spreading across the synapse. Two alternative strategies either by targeting tau protein itself or by improving the age-related physiological decline are currently racing to find the hopeful treatment for tauopathy. Undoubtedly, more studies are needed to combat this devastating condition that has already affected millions of people in our aging population.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 123 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 123 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 26 21%
Student > Ph. D. Student 20 16%
Researcher 12 10%
Student > Master 9 7%
Student > Doctoral Student 5 4%
Other 10 8%
Unknown 41 33%
Readers by discipline Count As %
Neuroscience 28 23%
Biochemistry, Genetics and Molecular Biology 22 18%
Medicine and Dentistry 8 7%
Pharmacology, Toxicology and Pharmaceutical Science 6 5%
Chemistry 5 4%
Other 12 10%
Unknown 42 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2018.
All research outputs
#3,417,018
of 25,385,509 outputs
Outputs from Journal of Biomedical Science
#139
of 1,101 outputs
Outputs of similar age
#64,965
of 339,365 outputs
Outputs of similar age from Journal of Biomedical Science
#2
of 11 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,101 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.1. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 339,365 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.