Title |
DNA methylation landscapes in the pathogenesis of type 2 diabetes mellitus
|
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Published in |
Nutrition & Metabolism, June 2018
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DOI | 10.1186/s12986-018-0283-x |
Pubmed ID | |
Authors |
Zheng Zhou, Bao Sun, Xiaoping Li, Chunsheng Zhu |
Abstract |
Although genetic variations and environmental factors are vital to the development and progression of type 2 diabetes mellitus (T2DM), emerging literature suggest that epigenetics, especially DNA methylation, play a key role in the pathogenesis of T2DM by affecting insulin secretion of pancreatic β cells and the body's resistance to insulin. Previous studies have elucidated how DNA methylation interacted with various factors in T2DM pathogenesis. This review summarized the role of related methylation genes in insulin-sensitive organs, such as pancreatic islets, skeletal muscle, liver, brain and adipose tissue, as well as peripheral blood cells, comparing the tissue similarity and specificity of methylated genes, aiming at a better understanding of the pathogenesis of T2DM and providing new ideas for the personalized treatment of this metabolism-associated disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 92 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 18 | 20% |
Student > Master | 13 | 14% |
Researcher | 5 | 5% |
Lecturer | 5 | 5% |
Student > Doctoral Student | 5 | 5% |
Other | 16 | 17% |
Unknown | 30 | 33% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 18 | 20% |
Medicine and Dentistry | 10 | 11% |
Nursing and Health Professions | 9 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 8% |
Agricultural and Biological Sciences | 7 | 8% |
Other | 7 | 8% |
Unknown | 34 | 37% |