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Molecular diversity and function of jasmintides from Jasminum sambac

Overview of attention for article published in BMC Plant Biology, July 2018
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Title
Molecular diversity and function of jasmintides from Jasminum sambac
Published in
BMC Plant Biology, July 2018
DOI 10.1186/s12870-018-1361-y
Pubmed ID
Authors

Geeta Kumari, Ka Ho Wong, Aida Serra, Joon Shin, Ho Sup Yoon, Siu Kwan Sze, James P. Tam

Abstract

Jasmintides jS1 and jS2 from Jasminum sambac were previously identified as a novel family of cysteine-rich peptides (CRPs) with an unusual disulfide connectivity. However, very little else is known about jasmintides, particularly their molecular diversity and functions. Here, we report the discovery and characterization of a novel suite of jasmintides from J. sambac using transcriptomic, peptidomic, structural and functional tools. Transcriptomic analysis of leaves, flowers and roots revealed 14 unique jasmintide precursors, all of which possess a three-domain architecture comprising a signal peptide, a pro-domain and a mature jasmintide domain. Peptidomic analysis, using fractionated mixtures of jasmintides and chemical derivatization of cysteine to pseudolysine, trypsin digestion and MS/MS sequencing, revealed an additional 86 jasmintides, some of which were post-translationally modified. NMR analysis showed that jasmintide jS3 has three anti-parallel β-strands with a three-disulfide connectivity of CysI-CysV, CysII-CysIV and CysIII-CysVI, which is similar to jasmintide jS1. Jasmintide jS3 was able to withstand thermal, acidic and enzymatic degradation and, importantly, exhibited antifeedant activity against mealworm Tenebrio molitor. Together, this study expands the existing library of jasmintides and furthers our understanding of the molecular diversity and cystine framework of CRPs as scaffolds and tools for engineering peptides targeting pests.

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Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 28%
Student > Master 3 17%
Student > Bachelor 2 11%
Other 1 6%
Lecturer 1 6%
Other 2 11%
Unknown 4 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 22%
Biochemistry, Genetics and Molecular Biology 3 17%
Pharmacology, Toxicology and Pharmaceutical Science 2 11%
Medicine and Dentistry 2 11%
Chemistry 2 11%
Other 0 0%
Unknown 5 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2018.
All research outputs
#11,734,752
of 13,218,736 outputs
Outputs from BMC Plant Biology
#1,372
of 1,745 outputs
Outputs of similar age
#230,482
of 266,390 outputs
Outputs of similar age from BMC Plant Biology
#1
of 1 outputs
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