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Antidepressant prescribing in Irish children: secular trends and international comparison in the context of a safety warning

Overview of attention for article published in BMC Pediatrics, September 2015
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  • Above-average Attention Score compared to outputs of the same age (54th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

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Title
Antidepressant prescribing in Irish children: secular trends and international comparison in the context of a safety warning
Published in
BMC Pediatrics, September 2015
DOI 10.1186/s12887-015-0436-2
Pubmed ID
Authors

K. O’Sullivan, F. Boland, U. Reulbach, N. Motterlini, D. Kelly, K. Bennett, T. Fahey

Abstract

In 2003, the Irish Medicines Board (IMB) warned against the treatment of childhood depression with selective serotonin reuptake inhibitors (SSRIs) due to increased risk of suicide. This study examined the effect of this warning on the prevalence of anti-depressants in Irish children and compared age and gender trends and international comparisons of prescription rates. A retrospective cohort study of the Irish Health Service Executive (HSE) pharmacy claims database for the General Medical Services (GMS) scheme for dispensed medication. Data were obtained for 2002-2011 for those aged ≤15 years. Prevalence of anti-depressants per 1000 eligible population, along with 95 % confidence intervals, were calculated. A negative binomial regression analysis was used to investigate trends and compare rates across years, sex and age groups (0-4, 5-11, 12-15 years). International prescribing data were retrieved from the literature. The prevalence of anti-depressants decreased from 4.74/1000 population (95 % CI: 4.47-5.01) in 2002 to 2.61/1000 population (95 % CI: 2.43-2.80) in 2008. SSRI rates decreased from 2002 to 2008. Prescription rates for contra-indicated SSRIs paroxetine, sertraline and citralopram decreased significantly from 2002 to 2005, and, apart from paroxetine, only small fluctuations were seen from 2005 onwards. Fluoxetine was the most frequently prescribed anti-depressant and rates increased between 2002 and 2011. Anti-depressant rates were higher for younger boys and older girls. The Irish prevalence was lower than the US, similar to the U.K. and higher than Germany and Denmark. The direction and timing of these trends suggest that medical practitioners followed the IMB advice.

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X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 2%
Unknown 53 98%

Demographic breakdown

Readers by professional status Count As %
Other 8 15%
Student > Master 6 11%
Researcher 5 9%
Student > Ph. D. Student 5 9%
Student > Bachelor 4 7%
Other 14 26%
Unknown 12 22%
Readers by discipline Count As %
Medicine and Dentistry 21 39%
Biochemistry, Genetics and Molecular Biology 3 6%
Agricultural and Biological Sciences 3 6%
Nursing and Health Professions 2 4%
Materials Science 2 4%
Other 11 20%
Unknown 12 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2015.
All research outputs
#13,096,627
of 22,828,180 outputs
Outputs from BMC Pediatrics
#1,577
of 3,006 outputs
Outputs of similar age
#120,965
of 267,781 outputs
Outputs of similar age from BMC Pediatrics
#23
of 63 outputs
Altmetric has tracked 22,828,180 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,006 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,781 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.