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Resilience to infection by Mycobacterium avium subspecies paratuberculosis following direct intestinal inoculation in calves

Overview of attention for article published in Veterinary Research, July 2018
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  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (70th percentile)

Mentioned by

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9 tweeters

Citations

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8 Dimensions

Readers on

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22 Mendeley
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Title
Resilience to infection by Mycobacterium avium subspecies paratuberculosis following direct intestinal inoculation in calves
Published in
Veterinary Research, July 2018
DOI 10.1186/s13567-018-0553-7
Pubmed ID
Authors

Kevin J. Stinson, Monica M. Baquero, Brandon L. Plattner

Abstract

Mycobacterium avium subspecies paratuberculosis (Map) is the cause of Johne's disease, a chronic enteritis of cattle. A significant knowledge gap is how persistence of Map within the intestinal tract after infection contributes to progression of disease. To address this, we exposed calves to Map by direct ileocecal Peyer's patch injection. Our objective was to characterize the persistence of Map in tissues, associated intestinal lesions, fecal Map shedding, and serum antibody responses, through the first 28-weeks post-inoculation (wpi). Previous work using this model showed 100% rate of Map infection in intestine and lymph node by 12 wpi. We hypothesized that direct inoculation of Map into the distal small intestine would induce intestinal Map infection with local persistence and progression towards clinical disease. However, our data show decreased persistence of Map in the distal small intestine and draining lymph nodes. We identified Map in multiple sections of distal ileum and draining lymph node of all calves at 4 and 12 wpi, but then we observed reduced Map in distal ileum at 20 wpi, and by 28 wpi we found that 50% of animals had no detectable Map in intestine or the lymph node. This provides evidence of resilience to Map infection following direct intestinal Map inoculation. Further work examining the immune responses and host-pathogen interactions associated with this infection model are needed to help elicit the mechanisms underlying resilience to Map infection.

Twitter Demographics

The data shown below were collected from the profiles of 9 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 23%
Student > Bachelor 2 9%
Student > Master 2 9%
Student > Ph. D. Student 2 9%
Student > Doctoral Student 1 5%
Other 3 14%
Unknown 7 32%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 7 32%
Agricultural and Biological Sciences 6 27%
Medicine and Dentistry 1 5%
Unknown 8 36%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 August 2018.
All research outputs
#4,838,943
of 19,887,219 outputs
Outputs from Veterinary Research
#223
of 1,086 outputs
Outputs of similar age
#85,561
of 292,011 outputs
Outputs of similar age from Veterinary Research
#1
of 1 outputs
Altmetric has tracked 19,887,219 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,086 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 292,011 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them