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Non-linear optical microscopy and histological analysis of collagen, elastin and lysyl oxidase expression in breast capsular contracture

Overview of attention for article published in European Journal of Medical Research, June 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (53rd percentile)

Mentioned by

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3 tweeters

Citations

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4 Dimensions

Readers on

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38 Mendeley
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Title
Non-linear optical microscopy and histological analysis of collagen, elastin and lysyl oxidase expression in breast capsular contracture
Published in
European Journal of Medical Research, June 2018
DOI 10.1186/s40001-018-0322-0
Pubmed ID
Authors

Patrina S. P. Poh, Verena Schmauss, Jacqui A. McGovern, Daniel Schmauss, Mohit P. Chhaya, Peter Foehr, Markus Seeger, Vasilis Ntziachristos, Dietmar W. Hutmacher, Martijn van Griensven, Jan-Thorsten Schantz, Elizabeth R. Balmayor

Abstract

Capsular contracture is one of the most common complications in surgical interventions for aesthetic breast augmentation or post-mastectomy breast reconstruction involving the use of silicone prostheses. Although the precise cause of capsular contracture is yet unknown, the leading hypothesis is that it is caused by long-term unresolved foreign body reaction towards the silicone breast implant. To authors' best knowledge, this is the first study that elucidates the presence of lysyl oxidase (LOX)-an enzyme that is involved in collagen and elastin crosslinking within fibrous capsules harvested from patients with severe capsular contracture. It was hypothesized that over-expression of LOX plays a role in the irreversible crosslinking of collagen and elastin which, in turn, stabilizes the fibrous proteins and contributes to the progression of capsular contracture. Eight fibrous capsules were collected from patients undergoing capsulectomy procedure, biomechanical testing was performed for compressive Young's moduli and evaluated for Type I and II collagen, elastin and LOX by means of non-linear optical microscopy and immunohistology techniques. Observations revealed the heterogeneity of tissue structure within and among the collected fibrous capsules. Regardless of the tissue structure, it has been shown that LOX expression was intensified at the implant-to-tissue interface. Our results indicate the involvement of LOX in the initiation of fibrous capsule formation which ultimately contributes towards the progression of capsular contracture.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 38 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 13%
Student > Master 4 11%
Student > Postgraduate 4 11%
Student > Bachelor 4 11%
Researcher 3 8%
Other 8 21%
Unknown 10 26%
Readers by discipline Count As %
Medicine and Dentistry 9 24%
Engineering 5 13%
Physics and Astronomy 3 8%
Nursing and Health Professions 2 5%
Agricultural and Biological Sciences 1 3%
Other 7 18%
Unknown 11 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 November 2019.
All research outputs
#8,828,351
of 16,148,319 outputs
Outputs from European Journal of Medical Research
#121
of 306 outputs
Outputs of similar age
#128,081
of 277,359 outputs
Outputs of similar age from European Journal of Medical Research
#1
of 1 outputs
Altmetric has tracked 16,148,319 research outputs across all sources so far. This one is in the 45th percentile – i.e., 45% of other outputs scored the same or lower than it.
So far Altmetric has tracked 306 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,359 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them