Title |
Oral vaccination of dogs: a well-studied and undervalued tool for achieving human and dog rabies elimination
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Published in |
Veterinary Research, July 2018
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DOI | 10.1186/s13567-018-0554-6 |
Pubmed ID | |
Authors |
Florence Cliquet, Anne-Laure Guiot, Michel Aubert, Emmanuelle Robardet, Charles E. Rupprecht, François-Xavier Meslin |
Abstract |
The mass vaccination of dogs is a proven tool for rabies prevention. Besides parenteral delivery of inactivated vaccines, over the past several decades, several self-replicating biologics, including modified-live, attenuated and recombinant viruses, have been evaluated for the oral vaccination of dogs against rabies. Vaccines are included within an attractive bait for oral consumption by free-ranging dogs. Due to the high affinity between dogs and humans, such biologics intended for oral vaccination of dogs (OVD) need to be efficacious as well as safe. Baits should be preferentially attractive to dogs and not to non-target species. Although many different types have been evaluated successfully, no universal bait has been identified to date. Moreover, high bait acceptance does not necessarily mean that vaccine efficacy and programmatic success is predictable. The use of OVD in the laboratory and field has demonstrated the safety and utility of this technology. Within a One Health context, OVD should be considered as part of a holistic plan for the global elimination of canine rabies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 25% |
United Kingdom | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 116 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 12% |
Student > Bachelor | 14 | 12% |
Researcher | 13 | 11% |
Student > Master | 12 | 10% |
Other | 9 | 8% |
Other | 14 | 12% |
Unknown | 40 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 25 | 22% |
Medicine and Dentistry | 10 | 9% |
Immunology and Microbiology | 8 | 7% |
Agricultural and Biological Sciences | 7 | 6% |
Biochemistry, Genetics and Molecular Biology | 6 | 5% |
Other | 20 | 17% |
Unknown | 40 | 34% |