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Treatment options for PNET liver metastases: a systematic review

Overview of attention for article published in World Journal of Surgical Oncology, July 2018
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Title
Treatment options for PNET liver metastases: a systematic review
Published in
World Journal of Surgical Oncology, July 2018
DOI 10.1186/s12957-018-1446-y
Pubmed ID
Authors

Giuseppe Nigri, Niccolò Petrucciani, Tarek Debs, Livia Maria Mangogna, Anna Crovetto, Giovanni Moschetta, Raffaello Persechino, Paolo Aurello, Giovanni Ramacciato

Abstract

Pancreatic neuroendocrine tumors (PNETs) are rare pancreatic neoplasms. About 40-80% of patients with PNET are metastatic at presentation, usually involving the liver (40-93%). Liver metastasis represents the most significant prognostic factor. The aim of this study is to present an up-to-date review of treatment options for patients with liver metastases from PNETs. A systematic literature search was performed using the PubMed database to identify all pertinent studies published up to May 2018. The literature search evaluated all the therapeutic options for patients with liver metastases of PNETs, including surgical treatment, loco-regional therapies, and pharmacological treatment. All the different treatment options showed particular indications in different presentations of liver metastases of PNET. Surgery remains the only potentially curative therapeutic option in patients with PNETs and resectable liver metastases, even if relapse rates are high. Efficacy of medical treatment has increased with advances in targeted therapies, such as everolimus and sunitinib, and the introduction of radiolabeled somatostatin analogs. Several techniques for loco-regional control of metastases are available, including chemo- or radioembolization. Treatment of patients with PNET metastases should be multidisciplinary and must be personalized according to the features of individual patients and tumors.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 79 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 11 14%
Researcher 8 10%
Student > Postgraduate 7 9%
Student > Doctoral Student 6 8%
Student > Ph. D. Student 6 8%
Other 17 22%
Unknown 24 30%
Readers by discipline Count As %
Medicine and Dentistry 42 53%
Biochemistry, Genetics and Molecular Biology 4 5%
Arts and Humanities 1 1%
Mathematics 1 1%
Philosophy 1 1%
Other 4 5%
Unknown 26 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 July 2018.
All research outputs
#18,643,992
of 23,096,849 outputs
Outputs from World Journal of Surgical Oncology
#1,026
of 2,065 outputs
Outputs of similar age
#252,546
of 327,152 outputs
Outputs of similar age from World Journal of Surgical Oncology
#13
of 26 outputs
Altmetric has tracked 23,096,849 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,065 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 22nd percentile – i.e., 22% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,152 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.