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Urea cycle disorder presenting as bilateral mesial temporal sclerosis – an unusual cause of seizures: a case report and review of the literature

Overview of attention for article published in Journal of Medical Case Reports, July 2018
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1 tweeter

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Title
Urea cycle disorder presenting as bilateral mesial temporal sclerosis – an unusual cause of seizures: a case report and review of the literature
Published in
Journal of Medical Case Reports, July 2018
DOI 10.1186/s13256-018-1750-8
Pubmed ID
Authors

Furene Sijia Wang, Denise Li Meng Goh, Hian Tat Ong

Abstract

Urea cycle disorders are secondary to defects in the system converting ammonia into urea, causing accumulation of ammonia and other byproducts which are neurotoxic. Ornithine transcarbamylase deficiency is the most common of the urea cycle disorders and frequently presents with coma or seizures during hyperammonemia. However, seizures can also occur without metabolic decompensation. We describe a 23-year-old Chinese woman with urea cycle disorder who presented with confusion due to focal seizures arising from the left frontotemporal region. Interestingly, her ammonia levels remained normal during the seizures. Neuroimaging showed bilateral mesial temporal sclerosis. Her seizures were successfully controlled with two anti-epileptic medications. This case adds evidence of the predisposition of the temporal lobe to injury in urea cycle disorder. Urea cycle disorder can lead to mesial temporal sclerosis which leads to increased susceptibility of patients to seizures regardless of their metabolic state.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 30%
Librarian 1 10%
Other 1 10%
Student > Master 1 10%
Professor > Associate Professor 1 10%
Other 0 0%
Unknown 3 30%
Readers by discipline Count As %
Medicine and Dentistry 3 30%
Immunology and Microbiology 1 10%
Agricultural and Biological Sciences 1 10%
Nursing and Health Professions 1 10%
Neuroscience 1 10%
Other 0 0%
Unknown 3 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2018.
All research outputs
#10,554,908
of 13,253,522 outputs
Outputs from Journal of Medical Case Reports
#1,249
of 2,248 outputs
Outputs of similar age
#163,684
of 218,793 outputs
Outputs of similar age from Journal of Medical Case Reports
#1
of 1 outputs
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So far Altmetric has tracked 2,248 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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