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Antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg?

Overview of attention for article published in Arthritis Research & Therapy, April 2011
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Title
Antinuclear antibodies in healthy people: the tip of autoimmunity's iceberg?
Published in
Arthritis Research & Therapy, April 2011
DOI 10.1186/ar3282
Pubmed ID
Authors

David S Pisetsky

Abstract

Antinuclear antibodies (ANAs) are venerable biomarkers for assessing the diagnosis and prognosis of patients with autoimmunity. While closely associated with diseases such as systemic lupus erythematosus, ANA expression occurs commonly in healthy people. The basis for this expression is unknown, although it may reflect features of the assays for antibody detection or intrinsic immunological disturbances in otherwise normal individuals. Like autoimmunity itself, ANA expression is more common among women than men, pointing to an important determinant of these responses. Future research will clarify the mechanisms of ANA expression and the utility of current assays as antecedent and screening biomarkers.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Israel 1 2%
Colombia 1 2%
Germany 1 2%
Unknown 47 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 14%
Student > Master 6 12%
Student > Bachelor 5 10%
Professor 4 8%
Other 4 8%
Other 14 28%
Unknown 10 20%
Readers by discipline Count As %
Medicine and Dentistry 15 30%
Agricultural and Biological Sciences 6 12%
Immunology and Microbiology 6 12%
Biochemistry, Genetics and Molecular Biology 3 6%
Nursing and Health Professions 2 4%
Other 6 12%
Unknown 12 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 November 2011.
All research outputs
#17,285,036
of 25,371,288 outputs
Outputs from Arthritis Research & Therapy
#2,536
of 3,380 outputs
Outputs of similar age
#93,806
of 119,996 outputs
Outputs of similar age from Arthritis Research & Therapy
#19
of 27 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,380 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 119,996 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.