Title |
Interplay between acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria
|
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Published in |
Allergy, Asthma & Clinical Immunology, July 2018
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DOI | 10.1186/s13223-018-0255-8 |
Pubmed ID | |
Authors |
R. Grzanka, A. Damasiewicz-Bodzek, A. Kasperska-Zajac |
Abstract |
Chronic spontaneous urticaria (CSU) is associated with activation of systemic inflammatory response and coagulation/fibrinolysis. To study whether there is a relationship between the acute phase response and coagulation/fibrinolysis in chronic spontaneous urticaria (CSU) patients. Serum concentrations of C-reactive protein (CRP) and interleukin 6 (IL-6), key markers of acute phase response and of D-dimer, a marker of fibrin turnover were investigated in 58 CSU patients assessed with the urticaria activity score (UAS) and the controls. Serum concentrations of IL-6, CRP, and D-dimer were significantly higher in CSU patients as compared with the controls. We found statistically significant correlations between D-dimers concentrations and the inflammatory markers: CRP and IL-6 as well as UAS. Markers of inflammation (IL-6 and CRP) and of fibrinolysis (D-dimer) are related to each other in CSU, suggesting a possible cross-talk between inflammation and coagulation/fibrinolysis. It might be implicated in pathogenesis of the disease and may be associated with higher risks of cardiovascular diseases in CSU patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Canada | 1 | 25% |
United States | 1 | 25% |
United Kingdom | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 2 | 50% |
Members of the public | 1 | 25% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 14 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 3 | 21% |
Student > Postgraduate | 3 | 21% |
Student > Doctoral Student | 3 | 21% |
Other | 1 | 7% |
Researcher | 1 | 7% |
Other | 1 | 7% |
Unknown | 2 | 14% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 7 | 50% |
Biochemistry, Genetics and Molecular Biology | 2 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
Social Sciences | 1 | 7% |
Computer Science | 1 | 7% |
Other | 0 | 0% |
Unknown | 2 | 14% |