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Effect of CD14/TLR4 antagonist on GnRH/LH secretion in ewe during central inflammation induced by intracerebroventricular administration of LPS

Overview of attention for article published in Journal of Animal Science and Biotechnology, July 2018
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Citations

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18 Mendeley
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Title
Effect of CD14/TLR4 antagonist on GnRH/LH secretion in ewe during central inflammation induced by intracerebroventricular administration of LPS
Published in
Journal of Animal Science and Biotechnology, July 2018
DOI 10.1186/s40104-018-0267-8
Pubmed ID
Authors

Karolina Haziak, Andrzej Przemysław Herman, Karolina Wojtulewicz, Bartosz Pawlina, Kamila Paczesna, Joanna Bochenek, Dorota Tomaszewska-Zaremba

Abstract

Immune stress induced by lipopolysaccharide (LPS) influences the gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) secretion. Presence of LPS interacting Toll-like receptor (TLR) 4 in the hypothalamus may enable the direct action of LPS on the GnRH/LH secretion. So, the aim of the study was to investigate the influence of intracerebroventricular (icv) injection of TLR4 antagonist on GnRH/LH secretion in anestrous ewes during LPS-induced central inflammation. Animals were divided into three groups icv-treated with: Ringer-Locke solution, LPS and TLR4 antagonist followed by LPS. It was demonstrated that TLR4 antagonist reduced LPS-dependent suppression of GnRH gene expression in the preoptic area and in the medial basal hypothalamus, and suppression of receptor for GnRH gene expression in the anterior pituitary gland. It was also shown that TLR4 antagonist reduced suppression of LH release caused by icv injection of LPS. Central administration of LPS stimulated TLR4 gene expression in the medial basal hypothalamus. It was indicated that blockade of TLR4 prevents the inhibitory effect of centrally acting LPS on the GnRH/LH secretion. This suggests that some negative effects of bacterial infection on the hypothalamic-pituitary-gonadal axis activity at the hypothalamic level may be caused by central action of LPS acting through TLR4.

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 18 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 17%
Student > Master 3 17%
Lecturer > Senior Lecturer 1 6%
Other 1 6%
Professor 1 6%
Other 3 17%
Unknown 6 33%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 22%
Veterinary Science and Veterinary Medicine 2 11%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Psychology 1 6%
Other 3 17%
Unknown 6 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 July 2018.
All research outputs
#8,303,339
of 13,248,851 outputs
Outputs from Journal of Animal Science and Biotechnology
#144
of 307 outputs
Outputs of similar age
#158,994
of 267,143 outputs
Outputs of similar age from Journal of Animal Science and Biotechnology
#1
of 1 outputs
Altmetric has tracked 13,248,851 research outputs across all sources so far. This one is in the 23rd percentile – i.e., 23% of other outputs scored the same or lower than it.
So far Altmetric has tracked 307 research outputs from this source. They receive a mean Attention Score of 2.4. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,143 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them